Analysis of alpha 1L-adrenoceptor pharmacology in rat small mesenteric artery.

@article{Stam1999AnalysisOA,
  title={Analysis of alpha 1L-adrenoceptor pharmacology in rat small mesenteric artery.},
  author={Wiro B. Stam and Piet H van der Graaf and Pramod R. Saxena},
  journal={British journal of pharmacology},
  year={1999},
  volume={127 3},
  pages={661-70}
}
1. To illuminate the controversy on alpha 1A- or alpha 1L-adrenoceptor involvement in noradrenaline-mediated contractions of rat small mesenteric artery (SMA), we have studied the effects of subtype-selective alpha 1-adrenoceptor agonists and antagonists under different experimental conditions. 2. The agonist potency order in rat SMA was: A61603 >> SKF89748-A > cirazoline > noradrenaline > ST-587 > methoxamine. Prazosin antagonized all agonists with a low potency (pA2: 8.29-8.80) indicating the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…