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Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
Under conditions of tissue injury, myocardial replication and regeneration have been reported. A growing number of investigators have implicated adult bone marrow (BM) in this process, suggestingExpand
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Human tissue-engineered blood vessels for adult arterial revascularization
There is a crucial need for alternatives to native vein or artery for vascular surgery. The clinical efficacy of synthetic, allogeneic or xenogeneic vessels has been limited by thrombosis, rejection,Expand
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Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity
Background— Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of adverse cardiac drug reactionsExpand
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A nonviral minicircle vector for deriving human iPS cells
Owing to the risk of insertional mutagenesis, viral transduction has been increasingly replaced by nonviral methods to generate induced pluripotent stem cells (iPSCs). We report the use ofExpand
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Novel Index for Invasively Assessing the Coronary Microcirculation
Background—A relatively simple, invasive method for quantitatively assessing the status of the coronary microcirculation independent of the epicardial artery is lacking. Methods and Results—By usingExpand
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Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells.
Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder linked to arrhythmia and sudden cardiac death. While the causes of HCM have been identified as genetic mutationsExpand
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Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells
We here present an immunologic head-to-head comparison between human umbilical cord lining mesenchymal stem cells (clMSCs) and adult bone marrow MSCs (bmMSCs) from patients >65 years of age. clMSCsExpand
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Transcriptional and Functional Profiling of Human Embryonic Stem Cell-Derived Cardiomyocytes
Human embryonic stem cells (hESCs) can serve as a potentially limitless source of cells that may enable regeneration of diseased tissue and organs. Here we investigate the use of human embryonic stemExpand
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Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells
  • N. Sun, N. Panetta, +8 authors J. Wu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 15 September 2009
Ectopic expression of transcription factors can reprogram somatic cells to a pluripotent state. However, most of the studies used skin fibroblasts as the starting population for reprogramming, whichExpand
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Risk factors for the development of obliterative bronchiolitis after lung transplantation.
BACKGROUND Acute rejection has emerged as an important risk factor for obliterative bronchiolitis after lung transplantation. We performed a multivariate analysis to assess the impact of additionalExpand
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