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A 285222

Known as: A-285222, A285222 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

A 185 cpd

Broader (1)

Pyrazoles

Papers overview

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2018
2018
EphA2 stimulates VCAM-1 expression through calcium-dependent NFAT1 activity.
2014
2014
Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice
Objective of the Study Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher… 
2014
2014
High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling
ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology… 
2013
2013
NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice.
Elevated reactive oxygen species are implicated in pulmonary hypertension (PH). Superoxide dismutase (SOD) limits superoxide… 
Highly Cited
2012
Highly Cited
2012
NFATc3 regulates trypsinogen activation, neutrophil recruitment, and tissue damage in acute pancreatitis in mice.
BACKGROUND & AIMS The signaling mechanisms that regulate trypsinogen activation and inflammation in acute pancreatitis (AP) are… 
2012
2012
Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B.
Highly Cited
2010
Highly Cited
2010
Nuclear Factor of Activated T‐cells (NFAT) regulates osteopontin expression in arterial smooth muscle in response to diabetes‐induced hyperglycemia
Hyperglycemia is a recognized risk factor for cardiovascular disease in diabetes. Recently we reported that high glucose… 
2007
2007
Nuclear translocation of calcineurin Aβ but not calcineurin Aα by platelet-derived growth factor in rat aortic smooth muscle
Calcineurin regulates the proliferation of many cell types through activation of the nuclear factor of activated T cells (NFAT… 
Highly Cited
2007
Highly Cited
2007
Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation.
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth… 
Highly Cited
2006
Highly Cited
2006
High Glucose Activates Nuclear Factor of Activated T Cells in Native Vascular Smooth Muscle
Objective—Hyperglycemia has been suggested to play a role in the development of vascular disease associated with diabetes… 
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