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A 285222

Known as: A-285222, A285222 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2018
01220042018

Related topics

Related topics

1 relation

Broader (1)

Pyrazoles

Related mentions per year

Related mentions per year

1950-2018
1960198020002020
A 285222
Pyrazoles

Papers overview

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2014
2014
High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling
ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology… (More)
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2013
2013
NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice.
Elevated reactive oxygen species are implicated in pulmonary hypertension (PH). Superoxide dismutase (SOD) limits superoxide… (More)
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2013
2013
Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice
OBJECTIVE OF THE STUDY Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher… (More)
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2012
2012
NFATc3 regulates trypsinogen activation, neutrophil recruitment, and tissue damage in acute pancreatitis in mice.
BACKGROUND & AIMS The signaling mechanisms that regulate trypsinogen activation and inflammation in acute pancreatitis (AP) are… (More)
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2012
2012
Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B.
The incretin - glucose-dependent insulinotropic polypeptide (GIP) - and the pro-inflammatory cytokine osteopontin are known to… (More)
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2010
2010
Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia.
OBJECTIVE Hyperglycemia is a recognized risk factor for cardiovascular disease in diabetes. Recently, we reported that high… (More)
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2007
2007
Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation.
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth… (More)
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2007
2007
Nuclear translocation of calcineurin A but not calcineurin A by platelet-derived growth factor in rat aortic smooth muscle
Jabr RI, Wilson AJ, Riddervold MH, Jenkins AH, Perrino BA, Clapp LH. Nuclear translocation of calcineurin A but not calcineurin A… (More)
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2006
2006
High glucose activates nuclear factor of activated T cells in native vascular smooth muscle.
OBJECTIVE Hyperglycemia has been suggested to play a role in the development of vascular disease associated with diabetes… (More)
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2004
2004
Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT.
A-285222 (A-285) is a bis-trifluoromethyl-pyrazole (BTP), a novel class of immunosuppressive agents that inhibit NFAT activity in… (More)
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