• Publications
  • Influence
M Protein, a Classical Bacterial Virulence Determinant, Forms Complexes with Fibrinogen that Induce Vascular Leakage
Increased vascular permeability is a key feature of inflammatory conditions. In severe infections, leakage of plasma from the vasculature induces a life-threatening hypotension. StreptococcusExpand
  • 310
  • 11
Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability
Polymorphonuclear leukocyte infiltration into tissues in host defense and inflammatory disease causes increased vascular permeability and edema formation through unknown mechanisms. Here, we reportExpand
  • 310
  • 9
The dual role of the contact system in bacterial infectious disease.
Hemostasis is a sensitive and tightly regulated process, involving the vascular endothelium and blood cells as well as factors of the coagulation and fibrinolytic cascades. Over the last four decadesExpand
  • 128
  • 9
  • PDF
Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages.
In acute inflammation, infiltrating polymorphonuclear leukocytes (also known as PMNs) release preformed granule proteins having multitudinous effects on the surrounding environment. Here we presentExpand
  • 158
  • 8
  • PDF
Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.
Phylogenetically conserved serine protease cascades play an important role in invertebrate and vertebrate immunity. The mammalian coagulation system can be traced back some 400 million years andExpand
  • 145
  • 8
  • PDF
Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles.
Human neutrophils have an important role in host defense against microbial infection. At different stages of an infectious process, neutrophils progressively up-regulate receptors and release variousExpand
  • 136
  • 8
  • PDF
Pathogen Entrapment by Transglutaminase—A Conserved Early Innate Immune Mechanism
Clotting systems are required in almost all animals to prevent loss of body fluids after injury. Here, we show that despite the risks associated with its systemic activation, clotting is a hithertoExpand
  • 140
  • 7
  • PDF
Heparin-binding protein: an early marker of circulatory failure in sepsis.
BACKGROUND The early detection of circulatory failure in patients with sepsis is important for successful treatment. Heparin-binding protein (HBP), released from activated neutrophils, is a potentExpand
  • 115
  • 6
  • PDF
Streptococcal M Protein: A Multipotent and Powerful Inducer of Inflammation1
Severe infections with Streptococcus pyogenes, an important human pathogen, are associated with massive inflammatory reactions in the human host. Here we show that streptococcal M protein interactsExpand
  • 144
  • 6
Neutrophil secretion products pave the way for inflammatory monocytes.
The leukocyte response in inflammation is characterized by an initial recruitment of polymorphonuclear leukocytes (PMN) preceding a second wave of monocytes to the site of injury or infection. In theExpand
  • 328
  • 5