Streptococcal M1 protein triggers chemokine formation, neutrophil infiltration, and lung injury in an NFAT-dependent manner.

@article{Zhang2015StreptococcalMP,
  title={Streptococcal M1 protein triggers chemokine formation, neutrophil infiltration, and lung injury in an NFAT-dependent manner.},
  author={Songen Zhang and Su Zhang and Eliana Garcia-Vaz and Heiko Herwald and Maria F. Gomez and Henrik Thorlacius},
  journal={Journal of leukocyte biology},
  year={2015},
  volume={97 6},
  pages={1003-10}
}
Streptococcus pyogenes of the M1 serotype can cause STSS, which is associated with significant morbidity and mortality. The purpose of the present study was to examine the role of NFAT signaling in M1 protein-induced lung injury. NFAT-luc mice were treated with the NFAT inhibitor A-285222 before administration of the M1 protein. Neutrophil infiltration, edema, and CXC chemokines were quantified in the lung, 4 h after challenge with the M1 protein. Flow cytometry was used to determine Mac-1… CONTINUE READING
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