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A 182086

Known as: A-182086, A182086 
National Institutes of Health

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2 relations

Broader (2)

PyrrolidinesSulfonamides

Papers overview

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2013
2013
Chronic elevation of IL-1β induces diuresis via a cyclooxygenase 2-mediated mechanism.
Chronic renal inflammation is an increasingly recognized phenomenon in multiple disease states, but the impact of specific… 
2004
2004
Role of the Endothelin System in Secondary Pulmonary Hypertension Related to Air Embolism: Lessons Learned from Testing Four Classes of Endothelin Blockers in a Rat Model
A rat model of acute pulmonary air embolism (APAE) was developed. These animals had a higher right ventricular systolic pressure… 
2003
2003
Endothelin-receptor blockade mitigates the adverse effect of preretrieval warm ischemia on posttransplantation renal function in rats1
Background. Ischemia-reperfusion injury has been established as a nonimmunologic risk factor for the development of chronic graft… 
Highly Cited
2002
Highly Cited
2002
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies.
Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases, bind to ET(A) and ET(B) receptors to… 
2002
2002
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies.
Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases, bind to ET(A) and ET(B) receptors to… 
2002
2002
Endothelin receptor blockade during hypothermic perfusion preservation mitigates the adverse effect of preretrieval warm ischemic injury on posttransplant glomerular filtration rate1
Background. Preretrieval warm ischemic injury predisposes to both short-term and long-term dysfunction of cadaveric renal… 
2001
2001
Differential Effects of Endothelin A and B Receptor Antagonism on Fetal Growth in Normal and Nitric Oxide-Deficient Rats
Objective: To determine the role of endothelin (ET) in fetal and placental growth in rats with and without long-term nitric oxide… 
2001
2001
Effect of an ETB-selective and a mixed ETA/B endothelin receptor antagonist on venomotor tone in deoxycorticosterone–salt hypertension
Objectives Because the ETB receptor is important in venoconstriction, we examined the effects of a selective ETB receptor… 
2000
2000
Type A, but not type B, endothelin receptor antagonists significantly decrease portal pressure in portal hypertensive rats.
1999
1999
Differentiated effects on splanchnic homeostasis by selective and non‐selective endothelin receptor antagonism in porcine endotoxaemia
The non‐selective endothelin (ET) receptor antagonist bosentan has been shown to restore systemic and gut oxygen delivery and… 
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