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Endothelin-1 Increases Vascular Superoxide via EndothelinA–NADPH Oxidase Pathway in Low-Renin Hypertension
Background—Angiotensin II–induced hypertension is associated with NAD(P)H oxidase–dependent superoxide production in the vessel wall. Vascular superoxide level is also increased inExpand
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  • Open Access
Function of opioids in the enteric nervous system
  • J. Wood, J. Galligan
  • Medicine
  • Neurogastroenterology and motility : the official…
  • 8 September 2004
Alterations in gastrointestinal motility and secretion underlie the constipating action of therapeutically administered opiates. The prototype opiate is morphine, which acts to delay gastric emptyingExpand
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Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.
BACKGROUND & AIMS 5-hydroxytryptamine receptor (5-HT(4)R) agonists promote gastrointestinal motility and attenuate visceral pain, but concerns about adverse reactions have restricted theirExpand
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  • Open Access
Ligand‐gated ion channels in the enteric nervous system
  • J. Galligan
  • Medicine
  • Neurogastroenterology and motility : the official…
  • 1 December 2002
Abstract There are many cell surface receptors expressed by neurones in the enteric nervous system (ENS). These receptors respond to synaptically released neurotransmitters, circulating hormones andExpand
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State-dependent cross-inhibition between transmitter-gated cation channels
Transmitter-gated cation channels are detectors of excitatory chemical signals at synapses in the nervous system. Here we show that structurally distinct α3β4 nicotinic and P2X2 channels influenceExpand
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Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.
The conformationally restricted, cyclic, disulfide-containing, enkephalin analogs [2-D-penicillamine, 5-L-penicillamine]enkephalin [(D-Pen2,L-Pen5]enkephalin) and [2-D-penicillamine,Expand
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P2X purinoceptors in cultured myenteric neurons of guinea‐pig small intestine.
1. Fast excitatory postsynaptic currents (fEPSCs) and responses to exogenously applied purinoceptor agonists were studied in primary cultures of myenteric neurons from guinea‐pig small intestine.Expand
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Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting
Background  Despite the relatively high prevelance of gastroparesis and functional dyspepsia, the aetiology and pathophysiology of these disorders remain incompletely understood. Similarly, theExpand
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Purinergic fast excitatory postsynaptic potentials in myenteric neurons of guinea pig: distribution and pharmacology.
BACKGROUND & AIMS Adenosine triphosphate (ATP) acting at P2 receptors mediates some fast excitatory postsynaptic potentials (fEPSPs) in myenteric neurons of guinea pig ileum. The present studiesExpand
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Contribution of chloride conductance increase to slow EPSC and tachykinin current in guinea‐pig myenteric neurones.
1. Single electrode voltage clamp recordings were obtained from myenteric neurones of guinea‐pig ileum in vitro. Slow excitatory postsynaptic currents (sEPSCs) were elicited by focal stimulation ofExpand
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