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Endothelin-1 Increases Vascular Superoxide via EndothelinA–NADPH Oxidase Pathway in Low-Renin Hypertension
Background—Angiotensin II–induced hypertension is associated with NAD(P)H oxidase–dependent superoxide production in the vessel wall. Vascular superoxide level is also increased inExpand
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Gene Transfer of Human Guanosine 5′-Triphosphate Cyclohydrolase I Restores Vascular Tetrahydrobiopterin Level and Endothelial Function in Low Renin Hypertension
Background—We recently reported that arterial superoxide (O2−) is augmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a model of low reninExpand
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Regional blood flow measurement with pulsed Doppler flowmeter in conscious rat.
Development of techniques for the continuous measurement of regional blood flow and vascular resistance in intact small animals has been impeded primarily by the bulkiness of flow probes. TheExpand
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Area postrema is critical for angiotensin-induced hypertension in rats.
The effect of surgical ablation of the area postrema on acute (5-10 minutes) and chronic (5-10 days) increases in mean arterial pressure produced by intravenous infusion of angiotensin II inExpand
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Chemerin Connects Fat to Arterial Contraction
Objective—Obesity and hypertension are comorbid in epidemic proportion, yet their biological connection is largely a mystery. The peptide chemerin is a candidate for connecting fat deposits aroundExpand
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A Comparison of Arteries and Veins in Oxidative Stress: Producers, Destroyers, Function, and Disease
Reactive oxygen species (ROS) are by-products of oxygen metabolism, normally present in low levels inside cells, where they participate in signaling processes. The delicate balance in the continuousExpand
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  • G. Fink
  • Medicine
  • Clinical and experimental pharmacology…
  • 1 January 1997
1. The peptide hormone angiotensin II (AngII) is acknowledged to be an important factor in the pathophysiology of hypertension. This is particularly the case in hypertension caused by luminalExpand
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NADPH Oxidase–Derived Superoxide Augments Endothelin-1–Induced Venoconstriction in Mineralocorticoid Hypertension
Abstract—Deoxycorticosterone acetate (DOCA)–salt hypertension is characterized by low renin/angiotensin but increased arterial superoxide levels. We have recently reported that the arterialExpand
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Circulating angiotensin II and dietary salt: Converging signals for neurogenic hypertension
Circulating angiotensin II (Ang II) combined with high salt intake increases sympathetic nerve activity (SNA) in some forms of hypertension. Ang II-induced increases in SNA are modest, delayed, andExpand
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Morphological and biochemical characterization of remodeling in aorta and vena cava of DOCA-salt hypertensive rats.
Arterial remodeling occurs in response to mechanical and neurohumoral stimuli. We hypothesized that veins, which are not exposed to higher pressures in hypertension, would demonstrate less activeExpand
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