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9-cis-retinoic acid biosynthesis

Known as: 9-cis-retinoic acid synthesis, 9-cis-retinoic acid formation, 9-cis-retinoic acid biosynthetic process 
The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. [GOC:jl, PMID… 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Mouse Retinal Dehydrogenase 4 (RALDH4), Molecular Cloning, Cellular Expression, and Activity in 9-cis-Retinoic Acid Biosynthesis in Intact Cells*
This study describes cDNA cloning and characterization of mouse RALDH4. The 2.3-kb cDNA encodes an aldehyde dehydrogenase of 487… 
2002
2002
cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells.
9-cis-Retinoic acid activates retinoid X receptors, which serve as heterodimeric partners with other nuclear hormone receptors… 
2002
2002
Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions.
It has been proposed that cis-retinol dehydrogenase (cRDH) acts within the body to catalyze the oxidation of 9-cis-retinol, an… 
2000
2000
9-cis-retinoids: biosynthesis of 9-cis-retinoic acid.
Retinoids function through conformational alterations of ligand-dependent nuclear transcription factors, the retinoic acid… 
Highly Cited
2000
Highly Cited
2000
cDNA Cloning and Expression of a Human Aldehyde Dehydrogenase (ALDH) Active with 9-cis-Retinal and Identification of a Rat Ortholog, ALDH12*
This report describes the isolation of a heretofore uncharacterized aldehyde dehydrogenase (ALDH) with retinal dehydrogenase… 
1999
1999
Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/ reductase able to catalyze cis-retinol oxidation.
We have identified a retinol dehydrogenase (cRDH) that catalyzes the oxidation of 9-cis- but not all-trans-retinol and proposed… 
Highly Cited
1997
Highly Cited
1997
Identification and Characterization of a Stereospecific Human Enzyme That Catalyzes 9-cis-Retinol Oxidation
All-trans- and 9-cis-retinoic acid are active retinoids for regulating expression of retinoid responsive genes, serving as… 
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