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8-oxodGTPase

Known as: 7,8-Dihydro-8-Oxoguanine Triphosphatase, 8-oxo-7,8-dihydroguanosine triphosphatase, 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase 
7,8-dihydro-8-oxoguanine triphosphatase (197 aa, ~23 kDa) is encoded by the human NUDT1 gene. This protein is involved in the metabolism of both dGTP… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (3)

Alkaline PhosphataseDNA Repair EnzymesPhosphoric Monoester Hydrolases
CytoplasmEnzyme GeneHomo sapiensHydrolysis

Narrower (1)

NUDT1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Liver carcinogenesis and formation of 8-hydroxy-deoxyguanosine in C3H/HeN mice by oxidized dietary oils containing carcinogenic dicarbonyl compounds.
2001
2001
Analysis of MTH1 gene function in mice with targeted mutagenesis.
2000
2000
Induction of 8-oxo-dGTPase activity in human lymphoid cells and normal fibroblasts by oxidative stress.
2000
2000
Activity of the antimutagenic enzyme 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) in cultured chinese hamster ovary cells: effects of cell cycle, proliferation rate…
1999
1999
Cadmium(II), unlike nickel(II), inhibits 8-oxo-dGTPase activity and increases 8-oxo-dG level in DNA of the rat testis, a target organ for cadmium(II) carcinogenesis.
8-Oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) is an enzyme which prevents incorporation into DNA… 
1998
1998
Immunohistochemical Detection of 8-Hydroxy-2'-deoxyguanosine in Paraffin-Embedded Sections of Rat Liver after Carbon Tetrachloride Treatment
TO test the applicability of an anti-8-hydroxy-2'-deoxyguanosine (8-OH-dG) antibody for immunohistochemistry using paraffin… 
1997
1997
Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.
Highly Cited
1995
Highly Cited
1995
Mouse MTH1 Protein with 8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-Triphosphatase Activity That Prevents Transversion Mutation
8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal… 
Highly Cited
1995
Highly Cited
1995
cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides.
The enzyme, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase (8-oxo-dGTPase), is present in various organisms and plays an… 
1995
1995
Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.
The human MTH1 gene, a homolog of the E. coli mutator gene mutT, encodes 8-oxo-dGTPase that degrades a mutagenic substrate for… 
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