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Circadian oscillation of a mammalian homologue of the Drosophila period gene.

• Hajime Tei, Hideki Okamura, +4 authors Yuka Sakaki
• Nature
• 1997

Many biochemical, physiological and behavioural processes in organisms ranging from microorganisms to vertebrates exhibit circadian rhythms. In Drosophila, the gene period (per) is required for the… (More)

Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).

• H. Hashimoto, Norihito Shintani, +13 authors Atsuo Baba
• Proceedings of the National Academy of Sciences…
• 2001

Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably during evolution and is widely expressed in the mammalian brain. In Drosophila, mutation of the PACAP… (More)

Evaluation of three-dimensional finite element-based deformable registration of pre- and intraoperative prostate imaging.

• A Bharatha, M. Hirose, +10 authors C. M. Tempany
• Medical physics
• 2001

In this report we evaluate an image registration technique that can improve the information content of intraoperative image data by deformable matching of preoperative images. In this study,… (More)

Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals.

• Kou Ikejima, H. Honda, +4 authors N. Sato
• Hepatology
• 2001

Lines of evidence suggested a possible link between leptin and hepatic fibrosis; however, whether leptin modulates the fibrogenesis in the liver remains unclear. The purpose of this study, therefore,… (More)

Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2).

• Hiroko Hizaki, Eri Segi, +9 authors Ayumi Ichikawa
• Proceedings of the National Academy of Sciences…
• 1999

Female mice lacking the gene encoding the prostaglandin (PG) E(2) receptor subtype EP(2) (EP(2)(-/-)) become pregnant and deliver their pups at term, but with a much reduced litter size. A decrease… (More)

Implications of plasma concentrations of adiponectin in patients with coronary artery disease.

• Y. Nakamura, K. Shimada, +10 authors Junpei Yoshikawa
• Heart
• 2004

OBJECTIVE To investigate whether concentrations of plasma adiponectin constitute a significant coronary risk factor, with particular focus on the relation between plasma concentrations of adiponectin… (More)

The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.

• T. Shirai, Masaki Sano, +9 authors N. Ito
• Cancer research
• 1997

Prostate tissues obtained from rats given a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), at a dose of 400 ppm in the diet for 52 weeks were histopathologically… (More)

Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice.

• Eri Segi, Y. Sugimoto, +11 authors Ayumi Ichikawa
• Biochemical and biophysical research…
• 1998

The physiological role of the prostaglandin E2 receptor EP4 subtype was investigated by generation of EP4-deficient-mice by gene targeting. Loss of the EP4 receptor was not lethal in utero, but most… (More)

The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription.

• Ayumi Hida, N. Koike, M. Hirose, Masakazu Hattori, Yuka Sakaki, Hajime Tei
• Genomics
• 2000

The clock gene, Period1, from human and mouse was sequenced and characterized. Both human PERIOD1 (human PER1) and mouse Period1 (mouse Per1) consisted of 23 exons spanning approximately 16 kb, and… (More)

Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine.

• Shoji Fukushima, Hideki Wanibuchi, +11 authors Fumiko Furukawa
• Toxicological sciences : an official journal of…
• 2004

Until recently it has been generally considered that genotoxic carcinogens have no threshold in exerting their potential for cancer induction. However, the nonthreshold theory can be challenged with… (More)

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