8-azaxanthine

We describe a general protocol for using comparative NMR metabolomics data to infer in vivo efficacy, specificity and toxicity of… (More)

The coding potential of the genome of E. coli K-12 includes YgfO and YicE, two members of the evolutionarily conserved NAT/NCS2… (More)

The gene coding for urate oxidase, an enzyme that catalyzes the oxidation of uric acid to allantoin, is inactivated in humans… (More)

A series of 1,3-dimethyl- and 1,3-dipropyl-8-azaxanthines, substituted at the N8 or N7 position with substituents which usually… (More)

Bacillus subtilis mutants defective in purine metabolism have been isolated by selecting for resistance to purine analogs… (More)

Epithelial and fibroblast cells from adult rat liver were found to differ markedly in their sensitivities to the toxic effects of… (More)

Uricase (urate:oxygen oxidoreductase, EC 1.7.3.3) of Bacillus fastidiosus was purified to homogeneity in a two-step procedure and… (More)

Neurospora crassa can utilize various purine bases such as xanthine or uric acid and their catabolic products as a nitrogen… (More)

Hokin, L. E. & Hokin, M. R. (1959b). J. biol. Chem. 234, 1387. Ingle, D. J. (1954). Acta endocr., Kbh., 17, 172. Jones, M. E… (More)

Extensive efforts by the Burroughs-Wellcome group, the Sloan-Kettering group, and others have led to a considerable knowledge of… (More)