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6-thioxanthine

Known as: thioxanthine 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Up to 1/5 of patients with wildtype thiopurine-S-methyltransferase (TPMT) activity prescribed azathioprine (AZA) or… 
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Highly Cited
2009
Highly Cited
2009
An HPLC method has been developed and validated for the rapid determination of mercaptopurine and four of its metabolites… 
Highly Cited
2003
Highly Cited
2003
BACKGROUND Measurement of 6-thioguanine nucleotide (6-TGN) concentrations in erythrocytes is widely accepted for use in… 
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Highly Cited
1996
Highly Cited
1996
A nonhomologous integration vector was used to identify the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl… 
1996
1996
Genes that encode enzymes that convert inactive "prodrugs" into anticancer metabolites may be therapeutically useful against… 
Highly Cited
1995
Highly Cited
1995
Tumor cells become sensitive to the inert prodrug cyclophosphamide (CPA) after transfer of the gene encoding cytochrome P450 2B1… 
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Highly Cited
1994
Highly Cited
1994
6-Thioxanthine caused 50% inhibition of the growth of Toxoplasma gondii in human fibroblasts at a concentration of 5 micrograms… 
1987
1987
Thioxanthine is toxic for mammalian cells transformed by the dominant selectable marker gpt. It allowed us to select, in the… 
Highly Cited
1985
Highly Cited
1985
The bioavailability of oral mercaptopurine (MP) is poor, and plasma levels following p.o. dosing are highly variable. In an… 
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1975
1975
Phenothiazine derivatives were examined as potential antagonists of the inhibitory noradrenergic synapses from the nucleus locus…