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6-pyruvoyltetrahydropterin 2'-reductase activity

Known as: 6-pyruvoyl-tetrahydropterin 2'-reductase activity, 6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity, 6-pyruvoyltetrahydropterin reductase activity 
Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin. [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN… 
National Institutes of Health

Papers overview

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2012
2012
Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations
The enzyme 6-pyruvoyl-tetrahydropterin synthase (PTPS, gene symbol: PTS) is involved in the second step of the de novo… 
2009
2009
Dopamine agonists in 6-pyruvoyl tetrahydropterin synthase deficiency
Objective: To report the efficacy, tolerability, and safety of the dopamine agonist pramipexole in a series of 5 patients… 
2008
2008
Long-term follow-up of Taiwanese Chinese patients treated early for 6-pyruvoyl-tetrahydropterin synthase deficiency.
OBJECTIVE To report the long-term results of early initiation of treatment of 6-pyruvoyl-tetrahydropterin synthase (PTPS… 
Review
2006
Review
2006
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
2006
2006
Long‐term follow‐up and adult outcome of 6‐pyruvoyl‐tetrahydropterin synthase deficiency
Little information is available on the long‐term course and adult outcome of patients with 6‐pyruvoyl‐tetrahydropterin synthase… 
Highly Cited
1990
Highly Cited
1990
Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase…
1989
1989
Immunological studies on the participation of 6-pyruvoyl tetrahydropterin (2'-oxo) reductase, an aldose reductase, in tetrahydrobiopterin biosynthesis.
1989
1989
Biosynthetic pathways of pteridines and their association with phenotypic expression in vitro in normal and neoplastic pigment cells from goldfish.
The distribution of GTP-cyclohydrolase I, pyruvoyl tetrahydropterin (dysopropterin) synthase, and pyruvoyl tetrahydropterin… 
1984
1984
Intermediates in the enzymic synthesis of tetrahydrobiopterin in Drosophila melanogaster.
1963
1963
Tetrahydropterin und Melanophoren-Differenzierung bei Fischen
The pterins of adult fishes are located in special chromatophores, the “pterinophores”, where they are bound to protein granules… 
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