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Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform*
- H. Liu, M. Sugiura, +6 authors S. Spiegel
- Biology, Medicine
- The Journal of Biological Chemistry
- 30 June 2000
Sphingosine-1-phosphate (SPP) has diverse biological functions acting inside cells as a second messenger to regulate proliferation and survival, and extracellularly, as a ligand for G protein-coupled… Expand
Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
Epigenetic Signals The lipid sphingosine-1-phosphate (S1P) is a signaling molecule that binds to receptors on the cell surface to initiate biochemical changes that control a range of biological… Expand
SPHINGOSINE-1-PHOSPHATE: A MISSING COFACTOR FOR THE E3 UBIQUITIN LIGASE TRAF2
Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key component in NF-κB signalling triggered by TNF-α. Genetic evidence indicates that TRAF2 is necessary for the… Expand
Sphingosine-1-phosphate signaling and its role in disease.
The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer,… Expand
The outs and the ins of sphingosine-1-phosphate in immunity
The potent lipid mediator sphingosine-1-phosphate (S1P) is produced inside cells by two closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a crucial regulator of… Expand
SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism*
- M. Maceyka, H. Sankala, +9 authors S. Spiegel
- Medicine, Biology
- Journal of Biological Chemistry
- 4 November 2005
The potent sphingolipid metabolite sphingosine 1-phosphate is produced by phosphorylation of sphingosine catalyzed by sphingosine kinase (SphK) types 1 and 2. In contrast to pro-survival SphK1, the… Expand
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Inflammatory bowel disease is an important risk factor for colorectal cancer. We show that sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) links chronic… Expand
Sphingosine 1-Phosphate, a Key Cell Signaling Molecule*
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.
- M. Maceyka, S. Payne, S. Milstien, S. Spiegel
- Biology, Medicine
- Biochimica et biophysica acta
- 30 December 2002
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph… Expand
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including… Expand