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5-methylurapidil

Known as: 5-methyl-urapidil 
 
National Institutes of Health

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2 relations

Broader (2)

Adrenergic alpha-AntagonistsPiperazines

Papers overview

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2009
2009
The Impact of α1-Adrenoceptors Up-Regulation Accompanied by the Impairment of β-Adrenergic Vasodilatation in Hypertension
In human and animal hypertension models, increased activity of G-protein-coupled receptor kinase (GRK) 2 determines a generalized… Expand
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Highly Cited
2008
Highly Cited
2008
Smooth muscle α1D‐adrenoceptors mediate phenylephrine‐induced vasoconstriction and increases in endothelial cell Ca2+ in hamster cremaster arterioles
α1‐Adrenoceptor agonists induce Ca2+‐transients in endothelial cells (ECs) of arterioles. However, the presence of α1… Expand
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2008
2008
Influence of combined hypertension and renal failure on functional α1‐adrenoceptor subtypes in the rat kidney
Background and purpose: This study investigated whether the α1‐adrenoceptor responsiveness of the renal vasculature was altered… Expand
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Highly Cited
2006
Highly Cited
2006
A comparative in vitro study to determine the beneficial effect of calcium‐channel and α1‐adrenoceptor antagonism on human ureteric activity
To compare the in vitro human ureteric muscle response to calcium‐channel and α‐adrenoceptor antagonists, to determine the… Expand
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Highly Cited
2006
Highly Cited
2006
Heterodimers of α1B- and α1D-Adrenergic Receptors Form a Single Functional Entity
Heterologous expression of α1D-adrenergic receptors (α1D-ARs) in most cell types results in intracellular retention and little or… Expand
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Highly Cited
2002
Highly Cited
2002
Effects of selective alpha1- and alpha2-adrenergic blockade on coronary flow reserve after coronary stenting.
BACKGROUND Coronary flow reserve (CFR) is not normalized shortly after coronary stenting. We hypothesized that alpha-adrenergic… Expand
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Highly Cited
2000
Highly Cited
2000
α1-Adrenoceptor subtypes in rat renal resistance vessels : In vivo and in vitro studies
This study provides new information about the relative importance of different α1-adrenoceptors during norepinephrine (NE… Expand
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Highly Cited
2000
Highly Cited
2000
Pulmonary Release and Coronary and Peripheral Consumption of Big Endothelin and Endothelin-1 in Severe Heart Failure: Acute Effects of Vasodilator Therapy
BackgroundWe investigated plasma endothelin (ET) levels in patients with congestive heart failure (CHF) during treatment for… Expand
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Highly Cited
1994
Highly Cited
1994
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.
Molecular cloning studies have revealed the existence of three subtypes of alpha 1-adrenergic receptors. However, the link… Expand
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Highly Cited
1993
Highly Cited
1993
The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy.
alpha 1-Adrenergic agonists induce a hypertrophic phenotype in cultured neonatal rat ventricular myocytes. Quantifiable markers… Expand
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