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Differential vulnerability of neurochemically identified subpopulations of retinal neurons in a monkey model of glaucoma
The vulnerability of subpopulations of retinal neurons delineated by their content of cytoskeletal or calcium-binding proteins was evaluated in the retinas of cynomolgus monkeys in which glaucoma wasExpand
Magnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma.
PURPOSE Neurochemical changes in nerve cells were investigated in the lateral geniculate nucleus (LGN) and primary visual cortex of macaque monkeys with experimentally induced glaucoma. METHODSExpand
Signs of early damage in glaucomatous monkey eyes: low spatial frequency losses in the pattern ERG and VEP.
Experimental glaucoma was created in one eye of three cynomolgus monkeys by argon laser application to the mid-trabecular meshwork. Simultaneous pattern electroretinograms (PERG) and pattern visualExpand
MK-507 (L-671,152), a topically active carbonic anhydrase inhibitor, reduces aqueous humor production in monkeys.
An investigation was carried out to determine the mechanism by which MK-507 (L-671,152), a water-soluble inhibitor of human carbonic anhydrase II in vitro, reduces intraocular pressure when appliedExpand
A Comparison of Argon Laser and Diode Laser Photocoagulation of the Trabecular Meshwork to Produce the Glaucoma Monkey Model
Purpose: To create an experimental glaucoma monkey model using high-power diode laser photocoagulation of the trabecular meshwork, and to compare this with the experimental glaucoma monkey modelExpand
Effect of ticrynafen on aqueous humor dynamics in monkeys.
OBJECTIVE To determine the effect of ticrynafen, a nonsulfhydryl-reactive compound similar to ethacrynic acid, on outflow facility in normotensive monkey eyes and on intraocular pressure (IOP) inExpand
The ocular hypotensive effect of the topical carbonic anhydrase inhibitor L-671,152 in glaucomatous monkeys.
L-671,152, a new potent water-soluble inhibitor of human carbonic anhydrase II in vitro, was applied topically to cynomolgus monkey eyes in which glaucoma had been produced by argon laserExpand
A comparative study of latanoprost (Xalatan) and isopropyl unoprostone (Rescula) in normal and glaucomatous monkey eyes.
Latanoprost (PhXA41, Xalatan) and isopropyl unoprostone (UF-021, unoprostone, Rescula) two new prostanoid derivatives, have been shown to reduce intraocular pressure (IOP) significantly in patientsExpand
The role of prostaglandins in the para-aminoclonidine-induced reduction of intraocular pressure.
THE MECHANISM BY WHICH ADRENERGIC AGONISTS REDUCE INTRAOCUlar pressure (IOP) in glaucoma patients is unclear. Epinephrine, a mixed a and ,B-adrenergic agonist, has been used therapeutically forExpand
Effects of prostaglandins F2 alpha, A2, and their esters in glaucomatous monkey eyes.
The effect of prostaglandin (PG) F2 alpha-isopropyl ester (IE), PGA2, or PGA2-IE on intraocular pressure (IOP) was tested in eight cynomolgus monkey eyes with argon laser-induced glaucoma.Expand