5-methyldeoxycytidine

The base 5-hydroxymethylcytosine (5hmC) was recently identified as an oxidation product of 5-methylcytosine in mammalian DNA… (More)

PURPOSE The DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (decitabine) induces DNA demethylation and re-expression of… (More)

CpG island hypermethylation occurs in most cases of cancer, typically resulting in the transcriptional silencing of critical… (More)

Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and… (More)

The goal of the present study was to investigate inter-individual and age-dependent variation of global DNA methylation in human… (More)

Eukaryotic DNA is methylated at some cytosine residues, and this epigenetic feature performs critical functions. We developed a… (More)

It has been recently shown that in developing chicken embryonic nuclear extracts there is a 5-methyldeoxycytidine excision repair… (More)

Here I show that nuclear extracts of chicken embryos can promote the active demethylation of DNA. The evidence shows that in… (More)

Significant losses of DNA 5-methyldeoxycytidine residues in old age could disrupt cellular gene expression and contribute to the… (More)

Sodium bisulfite is a mutagen which can specifically deaminate more than 96% of the cytosine residues in single-stranded DNA via… (More)