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A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
TLDR
The results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status, and is known to be solely represented in those individuals.
Epigenetics: A New Bridge between Nutrition and Health.
TLDR
Current knowledge in nutritional epigenetics is limited, and further studies are needed to expand the available resources and better understand the use of nutrients or bioactive food components for maintaining the authors' health and preventing diseases through modifiable epigenetic mechanisms.
FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease.
TLDR
In populations following a Western diet, subjects carrying FADS haplotypes that are associated with higher desaturase activity may be prone to a proinflammatory response favoring atherosclerotic vascular damage.
Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease.
TLDR
The findings suggest that certain factor VII genotypes have a role in protection against myocardial infarction, and may explain why some patients do not have myocardials despite the presence of severe coronary atherosclerosis.
Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic
TLDR
The MTHFR C677T mutation is rather common, but it does not appear to be associated per se to CAD, and a genetic-environmental interaction may contribute to the vascular risk by elevating tHcy when folate status is low.
A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry.
TLDR
This LC/MS method for quantitative determination of genomic DNA methylation status is rapid, sensitive, selective, and precise.
Low Circulating Vitamin B6 Is Associated With Elevation of the Inflammation Marker C-Reactive Protein Independently of Plasma Homocysteine Levels
TLDR
Low plasma PLP is associated with higher CRP levels independently of tHcy, which may reflect a vitamin B6 utilization in the presence of an underlying inflammatory process and represent a possible mechanism to explain the decreased vitamin B 6 levels in CVD.
Resistance to activated protein C in healthy women taking oral contraceptives
Summary. Resistance to activated protein C (APC) is at present considered the most frequent laboratory abnormality in patients with deep‐vein thrombosis. An increased risk for venous thrombosis is
Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery disease Published, JLR Papers in Press, October 16, 2003. DOI 10.1194/jlr.M300253-JLR200
TLDR
Apolipoprotein C-III levels were significantly increased in MS patients, and the probability of having MS was correlated with increasing quartiles of apoC-II levels, while the carriership for the −455C variant multiplied the likelihood of CAD in MS in an allele-specific way and was associated with increased apoD-III and TG levels.
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