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5-hydroxymethyl-2'-deoxyuridine

Known as: 2'-deoxy-5-(hydroxymethyl)uridine, 5-hydroxymethyldeoxyuridine, alpha-hydroxythymidine 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antineoplastic AgentsThymidine
analogs & derivatives

Papers overview

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Highly Cited
2002
Highly Cited
2002
J‐binding protein increases the level and retention of the unusual base J in trypanosome DNA
The nuclear DNA of Trypanosoma brucei and other kinetoplastid flagellates contains the unusual base β‐d‐glucosyl… 
2001
2001
Levels of 5-hydroxymethyl-2'-deoxyuridine in DNA from blood of women scheduled for breast biopsy.
Systemic oxidative stress is thought to contribute to risk of various cancers, including breast cancer. DNA repair ability also… 
1999
1999
Alpha-tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2'-deoxyuridine (HMdU).
This study evaluated the effects of vitamin E (alpha-tocopherol) on oxidative DNA damage in a randomized double-blind Phase II… 
1993
1993
Recognition of oxidized DNA bases by sera of patients with inflammatory diseases.
1990
1990
Formation of 5-hydroxymethyl-2'-deoxyuridine in hepatic DNA of rats treated with gamma-irradiation, diethylnitrosamine, 2-acetylaminofluorene or the peroxisome proliferator ciprofibrate.
The peroxisome proliferator ciprofibrate was tested for its ability to induce DNA damage in the form of 5-hydroxymethyl-2… 
1989
1989
Effect of metals on nucleoside hydroperoxide, a product of ionizing radiation in DNA.
1989
1989
Effects of 5-hydroxymethyluracil and 3-aminobenzamide on the repair and toxicity of 5-hydroxymethyl-2'-deoxyuridine in mammalian cells.
5-Hydroxymethyl-2'-deoxyuridine (HmdUrd), a cytotoxic analogue of thymidine, has been proposed for use as an anticancer agent… 
1988
1988
Mutagenicity of 5-hydroxymethyl-2'-deoxyuridine to Chinese hamster cells.
5-Hydroxymethyluracil (HmUra) is formed from thymine in DNA through the action of ionizing radiation or reactive oxygen species… 
1988
1988
Metabolism, incorporation into DNA, and interactions with 1-beta-D-arabinofuranosylcytosine of 5-hydroxymethyl-2'-deoxyuridine in human promyelocytic leukemia cells (HL-60).
5-Hydroxymethyl-2'-deoxyuridine (5HmdUrd) and 1-beta-D-arabinofuranosylcytosine (Ara-C) had a dose-dependent synergistic or… 
1985
1985
5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells.
5-Hydroxymethyl-2'-deoxyuridine is a biologically active thymidine analogue. This investigation was aimed at characterizing the… 
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