Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- D. Harrison, R. Strong, Richard A. Miller
- BiologyNature
- 8 July 2009
It is reported that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age.
Estrogens as endogenous genotoxic agents--DNA adducts and mutations.
- E. Cavalieri, K. Frenkel, J. Liehr, E. Rogan, D. Roy
- Biology, ChemistryJournal of the National Cancer Institute…
- 1 July 2000
It is concluded that estrogens, including the natural hormones estradiol and estrone, must be considered genotoxic carcinogens on the basis of the evidence outlined in this chapter.
Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters.
- H. Wei, K. Frenkel
- Chemistry, BiologyCarcinogenesis
- 1 June 1993
The results strengthen the evidence that ROS are involved in tumor promotion, and that generation of ROS and the subsequent oxidative DNA modification are related to the tumor-promoting potencies of the different phorbol ester-type promoters.
Hydrogen peroxide formation by cells treated with a tumor promoter.
- K. Frenkel, C. Gleichauf
- Biology, ChemistryFree Radical Research Communications
- 1991
The results demonstrate that tumor promoters can cause oxidative activation of HeLa cells, which produce active oxygen species, most likely H2O2, that ultimately contribute to the formation of oxidized bases such as 5-hydroxymethyl uracil in cellular DNA.
Carcinogen-mediated oxidant formation and oxidative DNA damage.
- K. Frenkel
- BiologyPharmacology and Therapeutics
- 1992
Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer.
- Jing Wu, C. Omene, K. Frenkel
- Biology, MedicineCancer Letters
- 1 September 2011
Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein.
- H. Wei, L. Wei, K. Frenkel, R. Bowen, S. Barnes
- Biology, MedicineNutrition and Cancer
- 1993
It is reported that genistein, a soybean isoflavone, strongly inhibits tumor promoter-induced H2O2 formation both in vivo and in vitro and makes it a promising candidate for the prevention of human cancers.
In vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin.
- H. Wei, K. Frenkel
- Biology, ChemistryCancer Research
- 15 August 1991
The infiltration of polymorphonuclear leukocyte-specific myeloperoxidase might play an important role in TPA-induced DNA oxidation in vivo, and formation of oxidized DNA bases may be responsible for the genetic effects of tumor promoters in carcinogenesis.
Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by sarcophytol A: a possible mechanism of antipromotion.
- H. Wei, K. Frenkel
- Biology, ChemistryCancer Research
- 15 April 1992
Sarcophytol A (Sarp A), a nontoxic compound isolated from marine soft coral, inhibits the in vivo effects of tumor promoters. However, the mechanism of its action is unknown. Our studies show that…
Ultraviolet-B-induced oxidative DNA base damage in primary normal human epidermal keratinocytes and inhibition by a hydroxyl radical scavenger.
- E. Pelle, Xi Huang, T. Mammone, Kenneth D. Marenus, D. Maes, K. Frenkel
- Biology, MedicineJournal of Investigative Dermatology
- 1 July 2003
The induction of 8-oxo-dG is reported in normal human skin keratinocytes at ultraviolet-B doses relevant to human skin exposure, supported by the data showing that OH* scavengers, such as mannitol, are effective inhibitors of oxidative DNA base damage.
...
...