5-dehydrosparteine
National Institutes of Health
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Sparteine oxidation was polymorphic among 301 healthy Danish volunteers. Hence 22 subjects or 7.3% were phenotyped as poor…
Sparteine oxidation is part of a genetic polymorphism that affects the metabolism of many drugs and is under monogenic control…
Sparteine metabolism was studied in human liver microsomes from nine extensive ([EM] urinary metabolic ratio [MR] < 20) and four…
In eight patients a sparteine-test was carried out immediately before and after 1 week of treatment with quinidine 600-800 mg day…
The formation of the two major metabolites of the antiarrhythmic and oxytocic drug sparteine (2- and 5-dehydrosparteine) exhibits…
Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped…
The ability to oxidize sparteine to form 2‐ and 5‐dehydrosparteine was studied in 154 healthy Ghanaians. Although the urinary…
The frequency of genetically deficient hydroxylation of mephenytoin (M‐defect) was studied in 83 healthy Caucasians living in…
The capacity for sparteine (SP) metabolism was determined in 48 Caucasian subjects by measuring amounts of drug and…