5-dehydrosparteine
National Institutes of Health
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Sparteine oxidation was polymorphic among 301 healthy Danish volunteers. Hence 22 subjects or 7.3% were phenotyped as poor…
Abstract. Objective: To investigate the influence of CYP2D6 genotype and medication on the reliability of phenotyping in a…
MPTP-induced parkinsonism has revived interest in the role of environmental factors in the etiology of Parkinson's disease. Many…
Sparteine metabolism was studied in human liver microsomes from nine extensive ([EM] urinary metabolic ratio [MR] < 20) and four…
In eight patients a sparteine-test was carried out immediately before and after 1 week of treatment with quinidine 600-800 mg day…
A simple borohydride/GC method was developed for phenotyping sparteine oxidation in man. The major metabolites of sparteine found…
The frequency of genetically deficient hydroxylation of mephenytoin (M‐defect) was studied in 83 healthy Caucasians living in…
The capacity for sparteine (SP) metabolism was determined in 48 Caucasian subjects by measuring amounts of drug and…