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5-dehydrosparteine

National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Sparteine oxidation was polymorphic among 301 healthy Danish volunteers. Hence 22 subjects or 7.3% were phenotyped as poor… 
1989
1989
Sparteine oxidation is part of a genetic polymorphism that affects the metabolism of many drugs and is under monogenic control… 
Highly Cited
1986
Highly Cited
1986
In eight patients a sparteine-test was carried out immediately before and after 1 week of treatment with quinidine 600-800 mg day… 
Highly Cited
1986
Highly Cited
1986
The formation of the two major metabolites of the antiarrhythmic and oxytocic drug sparteine (2- and 5-dehydrosparteine) exhibits… 
Highly Cited
1985
Highly Cited
1985
The ability to oxidize sparteine to form 2‐ and 5‐dehydrosparteine was studied in 154 healthy Ghanaians. Although the urinary… 
Highly Cited
1984
Highly Cited
1984
The frequency of genetically deficient hydroxylation of mephenytoin (M‐defect) was studied in 83 healthy Caucasians living in… 
Highly Cited
1982
Highly Cited
1982
The capacity for sparteine (SP) metabolism was determined in 48 Caucasian subjects by measuring amounts of drug and… 
Highly Cited
1979
Highly Cited
1979
SummarySparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with…