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5-chlorouracil

 
National Institutes of Health

Related topics

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2 relations

Broader (1)

Uracil
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil.
We report on the shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil, as obtained from fixed-nuclei elastic… Expand
Highly Cited
2012
Highly Cited
2012
Direct Investigation of Covalently Bound Chlorine in Organic Compounds by Solid-State 35Cl NMR Spectroscopy and Exact Spectral Line-Shape Simulations''
35/37Cl NMR spectroscopy studies of organic systems are very rare, with only a few neat liquids having been studied.1 The lack of… Expand
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Highly Cited
2006
Highly Cited
2006
Myeloperoxidase Generates 5-Chlorouracil in Human Atherosclerotic Tissue
Somatic mutations induced by oxidative damage of DNA might play important roles in atherogenesis. However, the underlying… Expand
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Highly Cited
2003
Highly Cited
2003
Phagocytes Produce 5-Chlorouracil and 5-Bromouracil, Two Mutagenic Products of Myeloperoxidase, in Human Inflammatory Tissue*
Oxidative damage to DNA has been implicated in carcinogenesis during chronic inflammation. Epidemiological and biochemical… Expand
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2003
2003
5-Chlorouracil, a Marker of DNA Damage from Hypochlorous Acid during Inflammation
Hypochlorous acid (HOCl), generated from H2O2 and Cl– by myeloperoxidase in activated neutrophils, causes tissue damage during… Expand
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2001
2001
Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver.
Recently, we have reported that tegafur, an anticancer agent, is biotransformed into active drug 5-fluorouracil (5-FU) by… Expand
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Review
1993
Review
1993
The genetic toxicology of 5-fluoropyrimidines and 5-chlorouracil.
  • S. Morris
  • Mutation research
  • 1993
    • Corpus ID: 6702027
The halogenated pyrimidines were synthesized in the 1950s as potential anti-tumor agents after the discovery that certain tumors… Expand
Highly Cited
1992
Highly Cited
1992
Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
In order to study the structure-activity relationships of dioxolane nucleosides as potential anti-HIV agents, various… Expand
Highly Cited
1988
Highly Cited
1988
Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule.
The pharmacokinetics of 5-fluorouracil (5-FUra) was investigated in 21 patients with advanced cancer (mainly colorectal cancer… Expand
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Highly Cited
1957
Highly Cited
1957
Effects of 5-halogenated uracils on the growth of Escherichia coli and their incorporation into deoxyribonucleic acids.
A variety of structural analogues of purines and pyrimidines are known to affect the growth of viruses, bacteria and other micro… Expand
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