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5-chlorouracil

National Institutes of Health

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Broader (1)

Uracil
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications.
2014
2014
Shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil.
We report on the shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil, as obtained from fixed-nuclei elastic… 
2012
2012
A spectroscopic investigations of anticancer drugs binding to bovine serum albumin.
Highly Cited
2012
Highly Cited
2012
Direct Investigation of Covalently Bound Chlorine in Organic Compounds by Solid-State 35Cl NMR Spectroscopy and Exact Spectral Line-Shape Simulations''
35/37Cl NMR spectroscopy studies of organic systems are very rare, with only a few neat liquids having been studied.1 The lack of… 
Highly Cited
2006
Highly Cited
2006
Myeloperoxidase Generates 5-Chlorouracil in Human Atherosclerotic Tissue
Somatic mutations induced by oxidative damage of DNA might play important roles in atherogenesis. However, the underlying… 
Highly Cited
2003
Highly Cited
2003
Phagocytes Produce 5-Chlorouracil and 5-Bromouracil, Two Mutagenic Products of Myeloperoxidase, in Human Inflammatory Tissue*
Oxidative damage to DNA has been implicated in carcinogenesis during chronic inflammation. Epidemiological and biochemical… 
Highly Cited
2003
Highly Cited
2003
5-Chlorouracil, a Marker of DNA Damage from Hypochlorous Acid during Inflammation
Hypochlorous acid (HOCl), generated from H2O2 and Cl– by myeloperoxidase in activated neutrophils, causes tissue damage during… 
Highly Cited
2001
Highly Cited
2001
Determination of 5-fluorouracil in environmental samples by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection.
Highly Cited
1988
Highly Cited
1988
Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule.
The pharmacokinetics of 5-fluorouracil (5-FUra) was investigated in 21 patients with advanced cancer (mainly colorectal cancer… 
Highly Cited
1957
Highly Cited
1957
Effects of 5-halogenated uracils on the growth of Escherichia coli and their incorporation into deoxyribonucleic acids.
A variety of structural analogues of purines and pyrimidines are known to affect the growth of viruses, bacteria and other micro… 
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