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5-chlorouracil

 
National Institutes of Health

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2 relations

Broader (1)

Uracil
analogs & derivatives

Papers overview

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2014
2014
Shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil.
We report on the shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil, as obtained from fixed-nuclei elastic… Expand
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2009
2009
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil…
A rapid and selective liquid chromatography/tandem mass spectrometric method was developed for the simultaneous determination of… Expand
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2006
2006
Myeloperoxidase Generates 5-Chlorouracil in Human Atherosclerotic Tissue
Somatic mutations induced by oxidative damage of DNA might play important roles in atherogenesis. However, the underlying… Expand
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Highly Cited
2006
Highly Cited
2006
Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability.
Initiating the DNA base excision repair pathway, DNA glycosylases find and hydrolytically excise damaged bases from DNA. While… Expand
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2005
2005
5-Halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2)
Perturbations in cytosine methylation signals are observed in the majority of human tumors; however, it is as yet unknown how… Expand
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Highly Cited
2003
Highly Cited
2003
Phagocytes Produce 5-Chlorouracil and 5-Bromouracil, Two Mutagenic Products of Myeloperoxidase, in Human Inflammatory Tissue*
Oxidative damage to DNA has been implicated in carcinogenesis during chronic inflammation. Epidemiological and biochemical… Expand
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2003
2003
5-Chlorouracil, a Marker of DNA Damage from Hypochlorous Acid during Inflammation
Hypochlorous acid (HOCl), generated from H2O2 and Cl– by myeloperoxidase in activated neutrophils, causes tissue damage during… Expand
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Highly Cited
1997
Highly Cited
1997
Hypochlorous acid-induced base modifications in isolated calf thymus DNA.
Exposure of calf thymus DNA to hypochlorous acid/hypochlorite leads to extensive DNA base modification. Large concentration… Expand
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Review
1993
Review
1993
The genetic toxicology of 5-fluoropyrimidines and 5-chlorouracil.
The halogenated pyrimidines were synthesized in the 1950s as potential anti-tumor agents after the discovery that certain tumors… Expand
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Highly Cited
1988
Highly Cited
1988
Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule.
The pharmacokinetics of 5-fluorouracil (5-FUra) was investigated in 21 patients with advanced cancer (mainly colorectal cancer… Expand
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