4-hydroxyperoxy-trans-2-nonenal
National Institutes of Health
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Background: Oxidized lipids cause endothelial activation. Results: Endothelial activation by the lipid peroxidation product, 4…
P rotein carbonylation is a type of protein oxidation that can be promoted by reactive oxygen species. It usually refers to a…
The oxidation of lipids containing polyunsaturated omega-3 or omega-6 acyl groups, such as docosahexenoic, eicosapentenoic…
Protein carbonylation induced by reactive carbonyl species (RCS) generated by peroxidation of polyunsaturated fatty acids plays a…
Abnormal production of inflammatory cytokines and chemokines is a key feature of bacterial endotoxin, lipopolysaccharide (LPS…
Products of lipid peroxidation such as 4-hydroxy-trans-2-nonenal (HNE) trigger multiple signaling cascades that variably affect…
Mitochondria are a major source of superoxide, formed by the one-electron reduction of oxygen during electron transport…
Abstract— Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been shown to metabolize toxic aldehydes…
The metabolism of 4-hydroxy-trans-2-nonenal (HNE), an α,β-unsaturated aldehyde generated during lipid peroxidation, was studied…