Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production.

  title={Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production.},
  author={Martin D. Brand and Julie A. Buckingham and Telma C Esteves and Katherine M Green and Adrian J Lambert and Satomi Miwa and M. L. Prato Murphy and Julian L. Pakay and Darren A Talbot and Karim S Echtay},
  journal={Biochemical Society symposium},
Mitochondria are a major source of superoxide, formed by the one-electron reduction of oxygen during electron transport. Superoxide initiates oxidative damage to phospholipids, proteins and nucleic acids. This damage may be a major cause of degenerative disease and aging. In isolated mitochondria, superoxide production on the matrix side of the membrane is particularly high during reversed electron transport to complex I driven by oxidation of succinate or glycerol 3-phosphate. Reversed… CONTINUE READING


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