Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production.

@article{Brand2004MitochondrialSA,
  title={Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production.},
  author={Martin D. Brand and Julie A. Buckingham and Telma C Esteves and Katherine M Green and Adrian J Lambert and Satomi Miwa and M. L. Prato Murphy and Julian L. Pakay and Darren A Talbot and Karim S Echtay},
  journal={Biochemical Society symposium},
  year={2004},
  volume={71},
  pages={203-13}
}
Mitochondria are a major source of superoxide, formed by the one-electron reduction of oxygen during electron transport. Superoxide initiates oxidative damage to phospholipids, proteins and nucleic acids. This damage may be a major cause of degenerative disease and aging. In isolated mitochondria, superoxide production on the matrix side of the membrane is particularly high during reversed electron transport to complex I driven by oxidation of succinate or glycerol 3-phosphate. Reversed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 71 extracted citations

Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress

Journal of cellular and molecular medicine • 2014
View 6 Excerpts
Highly Influenced

Mitochondrial uncoupling in cancer cells: Liabilities and opportunities.

Biochimica et biophysica acta. Bioenergetics • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Free Radicals in Biology and Medicine, 3rd edn

B. Halliwell, J.M.C. Gutteridge
1999
View 3 Excerpts
Highly Influenced

Mitochondrial superoxide and aging

J. Vasquez-Vivar, B. Kalyanaraman, M. C. Kennedy
J. Biol • 2000

Similar Papers

Loading similar papers…