• Publications
  • Influence
Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
TLDR
It is suggested that intracoronary infusion of autologous CSCs is effective in improving LV systolic function and reducing infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.
The Late Phase of Preconditioning
  • R. Bolli
  • Medicine
    Circulation research
  • 24 November 2000
TLDR
The cardioprotective effects of late PC can be reproduced pharmacologically with clinically relevant agents (eg, NO donors, adenosine receptors agonists, endotoxin derivatives, or opioid receptor agonists), suggesting that this phenomenon might be exploited for therapeutic purposes.
Molecular and cellular mechanisms of myocardial stunning.
TLDR
An important implication of the phenomenon of myocardial stunning is that so-called chronic hibernation may in fact be the result of repetitive episodes of stunning, which have a cumulative effect and cause protracted postischemic dysfunction.
Human cardiac stem cells
TLDR
The identification in vitro of a class of human c-kit-positive cardiac cells that possess the fundamental properties of stem cells: they are self-renewing, clonogenic, and multipotent is reported.
Protein Kinase C&egr; Interacts With and Inhibits the Permeability Transition Pore in Cardiac Mitochondria
TLDR
It is hypothesized that protein-protein interactions between PKC&egr; and mitochondrial pore components may serve as a signaling mechanism to modulate pore function and thus engender cardioprotection, and in vitro studies demonstrated that PKC &egr ; can directly bind and phosphorylate VDAC1.
Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced
TLDR
Together, data show that PKCepsilon forms subcellular-targeted signaling modules with ERKs, leading to the activation of mitochondrialERKs.
Mechanism of Myocardial “Stunning”
  • R. Bolli
  • Medicine
    Circulation
  • 1 September 1990
TLDR
The concepts discussed in this review should provide not only a conceptual framework for further investigation of the pathophysiology of reversible ischemia-reperfusion injury but also a rationale for developing clinically applicable interventions designed to prevent postischemic ventricular dysfunction.
Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research.
  • R. Bolli
  • Medicine
    Journal of molecular and cellular cardiology
  • 1 November 2001
TLDR
The NO hypothesis of late PC has revealed a cytoprotective function of iNOS in the heart, a novel paradigm which has recently been extended to other tissues, including kidney and intestine.
Stem cell niches in the adult mouse heart.
TLDR
The recognition of long-term label-retaining cells provides functional evidence of resident CSCs in the myocardium, indicating that the heart is an organ regulated by a stem cell compartment.
Life and Death of Cardiac Stem Cells: A Paradigm Shift in Cardiac Biology
TLDR
This article reviews a large body of novel information obtained in favor of the notion that the mammalian heart has the inherent ability to continuously replace its parenchymal cells and that this unexpected characteristic has important implications in understanding myocardial homeostasis, cardiac aging, and tissue repair.
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