4-anilidopiperidine
National Institutes of Health
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Abstract Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its…
SummarySynopsisFentanyl is a synthetic opioid with short-acting analgesic activity after intravenous or subcutaneous…
Fentanyl is the prototype of the 4-anilidopiperidine class of synthetic opioid analgesics. This study was aimed to review the…
Remifentanil is a 4-anilidopiperidine mu-opioid analgesic which is rapidly metabolized by unspecific blood and tissue esterases…
Fentanyl, and its structural analogs lofentanil and sufentanil, are potent analgesics used clinically in the management of pain…
SummaryRemifentanil is a novel, short-acting μ-receptor opioid agonist currently in the late stages of development. A member of…
Conformational flexibility of the N-acyl portion of fentanyl-type analgetics was restricted through the synthesis of novel…
Eight analogs of the fentanyl-type analgesics, in which the piperidine ring is restricted into a boat conformation, were…
Relatively little information is available concerning the influence of conformational factors on the potent analgesic actions of…
Abstract: In view of the potency-enhancing effect of methyl substitution of the piperidine ring of the 4-phenylpiperidine…