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Fluorocitrate inhibition of aconitate hydratase and the tricarboxylate carrier of rat liver mitochondria.
The effect of biologically synthesized and purified fluorocitrate on the metabolism of tricarboxylate anions by isolated rat liver mitochondria was investigated and it was found that with citrate as substrate the inhibition by fluoride was partially competitive, whereas with cis-aconitate as substrates the inhibition was partially non-competitive. Expand
Control of gonadotrophin secretion in the female tammar wallaby (macropus eugenii).
A heterologous radioimmunoassay for tammar wallaby FSH, using an ovine FSH antiserum and a human FSH tracer, is described, which has proved useful in studies of the control of gonadotrophin secretion in intact male and in ovariectomized tammars. Expand
Macropodid marsupial luteinizing hormone: validation of assay procedures and changes in concentrations in plasma during the oestrous cycle in the female tammar wallaby (Macropus eugenii).
In this radioimmunoassay system highly purified ovine, rat human and kangaroo LH preparations demonstrated apparently parallel dose-response curves, as did serial dilutions of crude pituitary extracts from a wide range of Austrlian marsupial species and serial dilution of plasma from ovariectomized, oestrous and LH releasing hormone (LH-RH)-treated marsupials. Expand
Potential antitumor agents. Synthesis, reactivity, and cytoxicity of alpha-methylene carbonyl compounds.
The rate of cysteine addition appears to be relatively insensitive to changes in strain energy and neighboring groups, and the rate constant for reaction with Cysteine did not correlate with cytotoxicity. Expand
Molecular modeling of 5-HT3 receptor ligands
The purpose of this presentation is to highlight the significant structure-affinity relationships (SAFIR) and common geometrical features among 5-HT3 receptor ligands, and to describe the three-dimensional pharmacophore for the 5- HT3 recognition site derived from computational techniques. Expand
The mechanism by which monoamine oxidase inhibitors give rise to a non‐calcium‐dependent component in the depolarization‐induced release of 5‐HT from rat brain synaptosomes
The results suggest that the non‐Ca2+‐dependent component of release seen with high depolarizing concentrations of K+, particularly in the presence of monoamine oxidase inhibitors, is caused by the efflux of [3H]‐5‐HT through the plasma membrane carrier which seems to be activated during depolarization. Expand
In-vitro secretion of progesterone by the corpus luteum of the tammar wallaby, Macropus eugenii.
It is suggested that the corpus luteum is the main source of the rise in progesterone in the peripheral circulation at Days 5-8 of the delayed or non-delayed cycle and the tonic inhibition exerted by prolactin on the corpusluteum does not affect the steroidogenic capacity of the luteal tissue but may inhibit luteAL cell growth during quiescence. Expand
Expression of von Willebrand factor, P-selectin (CD62P) and thrombomodulin in human endothelial cells in culture modulated by cyclosporin A.
The results showed that CSA disturbed actively growing cells more severely than quiescent cells and might help to clarify the role of CSA in vascular disturbances in vivo. Expand
Chapter 2. Analgesics
Publisher Summary 5-HT 3 receptor antagonists have shown efficacy in animal models of visceral pain but have not been evaluated clinically. Recent studies have led to the discovery of the opiateExpand
Octahydro-1,2,3,4,4a,5,11,11a-pyrido[3,4-c][1,5]benzoxazepines: conformationally restricted fentanyl analogs
Abstract Synthesis, analgesic activity and preliminary molecular modeling studies of the cis- and trans-fused octahydro-1,2,3,4,4a,5,11,11a-pyrido[3,4-c][1,5]benzoxazepines8 and 9, the first rigidExpand