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Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
The results suggest that the cloned kappa and mu receptors have pharmacological characteristics similar to those of the endogenously expressed kappa 1 and mu receptor, respectively. Expand
International Union of Pharmacology. XII. Classification of opioid receptors.
The results show that data from published knowledge can be used to provide reliable, patient level, automated risk assessment, potentially reducing the cognitive burden on physicians and helping policy makers better prepare for future needs. Expand
Stress hormones: their interaction and regulation.
Together these agents appear to determine the complex physiologic responses to a variety of stressors. Expand
Molecular biology of somatostatin receptors
The availability of the cloned receptors will now allow for detailed structure-function analysis of SRIF receptors and will facilitate development of subtype-selective agonists and antagonists that could be useful in the treatment of central nervous system and endocrine disorders. Expand
Molecular biology of somatostatin receptors.
The first evidence for somatostatin-like activity came from studies of Krulich et al. (17), who described a factor in hypothalamic extracts that inhibited GH secretion from anterior pituitaries in culture. Expand
Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.
The affinities of a battery of SRIF analogues to bind to SRIF receptor subtypes SSTR1 (cloned somatostatin complex), SSTR2, and SSTR3, as well as their abilities to inhibit the release of growth hormone from anterior pituitary cells in vitro are investigated. Expand
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
- K. Yasuda, K. Raynor, +4 authors G. Bell
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 July 1993
RNA blotting studies and in situ hybridization histochemistry showed that kappa opioid receptor mRNA was expressed at high levels in brain in the neocortex, hippocampus, amygdala, medial habenula, hypothalamus, locus ceruleus, and parabrachial nucleus, suggesting that this receptor may play a role in arousal and regulation of autonomic and neuroendocrine functions. Expand
Expression of Mu opioid receptor mRNA in rat brain: An in situ hybridization study at the single cell level
- J. Delfs, H. Kong, +4 authors M. Chesselet
- Biology, Medicine
- The Journal of comparative neurology
- 1 July 1994
The dissociation between the presence of binding sites and absence of mRNA in some brain regions supports a presynaptic localization of μ opioid receptors in these areas, and new insights are provided into the receptor types and neuronal circuits involved in the effects of endogenous opioids and morphine. Expand
Molecular properties of somatostatin receptors
The cloning of these receptors has now opened up the possibility of more clearly investigating the functions of somatostatin in the brain and peripheral tissues and will facilitate the generation of new som atostatin drugs that may be employed for the treatment of a number of diseases. Expand