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4-Quinolones

Known as: 4-Quinolones [Chemical/Ingredient], 4 Quinolinones, 4-Oxoquinolines 
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as… 
National Institutes of Health

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Related topics

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Narrower (5)

2-heptyl-4-quinolone2-methyl-3-phenylaminomethylquinolin-4-one4-quinolone-3-carboxylic acidKSI-3716
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Broader (1)

Quinolone Antibacterial Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Direct Synthesis of 4-Quinolones via Copper-Catalyzed Intermolecular Cyclization of Anilines and Alkynes.
A unique and direct approach for constructing 4-quinolones from simple and readily available anilines and alkynes is described… 
2004
2004
4-quinolones inhibit biotransformation of caffeine
SummaryThe pharmacokinetics of caffeine, including formation of its major metabolite paraxanthine in plasma, has been… 
Highly Cited
2002
Highly Cited
2002
Ketene dithioacetals in the aza-Diels-Alder reaction with N-arylimines: a versatile approach to tetrahydroquinolines, 2,3-dihydro-4-quinolones, and 4-quinolones.
[reaction: see text] The first successful use of ketene dithioacetals as dienophiles in the aza-Diels-Alder reaction with N… 
1993
1993
4-Quinolone bactericidal mechanisms.
The bactericidal activity of nalidixic acid against Escherichia coli strain KL16 in nutrient broth was abolished by the addition… 
1992
1992
Induction of the SOS gene (umuC) by 4-quinolone antibacterial drugs.
Induction by the 4-quinolone group of antibacterial drugs of the umuC gene, the SOS function most involved in error-prone DNA… 
1991
1991
4-Quinolone-resistant Neisseria gonorrhoeae in the United Kingdom.
The auxotype, serogroup and antimicrobial susceptibility of 977 clinical isolates of Neisseria gonorrhoeae obtained at St Thomas… 
Review
1990
Review
1990
Potential mechanisms of resistance to the modern fluorinated 4-quinolones.
The 4-quinolones are broad-spectrum antibiotics for which plasmid-mediated resistance has not yet been identified. Bacteria are… 
1988
1988
Susceptibilities of Hong Kong isolates of multiply resistant Shigella spp. to 25 antimicrobial agents, including ampicillin plus sulbactam and new 4-quinolones
Seventy-two percent of 129 shigella isolates from two Hong Kong hospitals were Shigella flexneri. Twenty-six percent were S… 
1988
1988
Multicenter in vitro evaluation of lomefloxacin (NY-198, SC-47111), including tests against nearly 7,000 bacterial isolates and preliminary recommendations for susceptibility testing.
1984
1984
Simultaneous formation of 2- and 4-quinolones from quinolinium cations catalysed by aldehyde oxidase.
Quinolinium salts were incubated with partially purified aldehyde oxidase, and the products were separated by high-pressure… 
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