4-Quinolones

Known as: 4-Quinolones [Chemical/Ingredient], 4 Quinolinones, 4-Oxoquinolines 
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections in immunocompromised patients and those with… (More)
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Review
1997
Review
1997
For many years, DNA gyrase was thought to be responsible both for unlinking replicated daughter chromosomes and for controlling… (More)
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1996
1996
Twelve isolates of Salmonella typhi isolated in Vellore, India had reduced susceptibility to 4-quinolones (MIC of ciprofloxacin 0… (More)
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Review
1990
Review
1990
Because of the close structural relationship of the fluorinated 4-quinolones to the parent compound nalidixic acid the mechanism… (More)
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1989
1989
The SOS DNA repair system is induced in bacteria treated with 4-quinolones. However, whether the response exacerbates or repairs… (More)
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1989
1989
The fluorinated 4-quinolones are a "new" group of antibiotics with a broad antibacterial spectrum. They are already widely used… (More)
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Review
1988
Review
1988
Structural modification of the so-called 'first-generation' or 'urinary' quinolones has led to a considerable increase in their… (More)
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1988
1988
The pharmacokinetics of caffeine, including formation of its major metabolite paraxanthine in plasma, has been investigated in 12… (More)
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Highly Cited
1987
Highly Cited
1987
The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS… (More)
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1985
1985
Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half… (More)
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