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4'-deoxy-4'-iododoxorubicin

Known as: Iododoxorubicin, IDOX, 4'-deoxy-4'-IDX 
An iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural… 
National Institutes of Health

Related topics

Related topics

8 relations
Amyloid Fibril InteractionDNA IntercalationDNA Replication InhibitionDNA Strand Break

Broader (1)

Doxorubicin

Narrower (1)

FCE 21954

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
New Drug Therapy of Amyloidoses: Resorption of AL-Type Deposits With
Treatment scheme. The first patient was treated with a single high dose of I-DOX (100 mg/m2) as part of a high-dose chemotherapy… 
Review
2007
Review
2007
AL Amyloidosis with Renal Involvement
Primary (AL amyloidosis) is a systemic disease characterized by an amyloid deposition process in many organs, with unsatisfactory… 
2001
2001
Cell surface-directed interaction of anthracyclines leads to cytotoxicity and nuclear factor kappaB activation but not apoptosis signaling.
Anthracyclines are, above all, DNA intercalators, which induce genetic damage leading to cell death. However, increasing evidence… 
1998
1998
Scintigraphic imaging and turnover studies with iodine-131 labelled serum amyloid P component in systemic amyloidosis
Abstract. Radiolabelled serum amyloid P component (SAP) is a specific tracer for amyloid. Iodine-123 has ideal physical… 
Review
1997
Review
1997
Secondary ion mass spectrometry (SIMS) microscopy: A new tool for pharmacological studies in humans
  • P. FraguE. Kahn
  • Microscopy research and technique (Print)
  • 1997
  • Corpus ID: 28558061
The secondary ion mass spectrometry (SIMS) microscope has opened new fields in biological investigation because of its ability to… 
1996
1996
Effects of lipophilicity and protein binding on the hepatocellular uptake and hepatic disposition of two anthracyclines, doxorubicin and iododoxorubicin
Abstract The anthracyclines, in particular doxorubicin (DOX), have been used for the intra-arterial locoregional therapy of liver… 
1992
1992
Characterization of tumor cell resistance to 4'-deoxy-4'-iododoxorubicin developed in Ehrlich ascites cells in vivo.
Reduced drug accumulation is the most common functional change accompanying development of P-glycoprotein-associated multidrug… 
Highly Cited
1989
Highly Cited
1989
Correlation between growth inhibition and intranuclear doxorubicin and 4'-deoxy-4'-iododoxorubicin quantitated in living K562 cells by microspectrofluorometry.
Intranuclear drug concentration in cells treated with doxorubicin (DXR) or with 4'-deoxy-4'-iododoxorubicin (IDX) was measured by… 
Highly Cited
1989
Highly Cited
1989
Comparative cytotoxicity, DNA synthesis inhibition and drug incorporation of eight anthracyclines in a model of doxorubicin-sensitive and -resistant rat glioblastoma cells.
Highly Cited
1987
Highly Cited
1987
Markedly reduced levels of anthracycline-induced DNA strand breaks in resistant P388 leukemia cells and isolated nuclei.
DNA single-strand and double-strand breaks produced by doxorubicin and two anthracycline derivatives (4-demethoxy-daunorubicin… 
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