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DNA Intercalation

DNA Intercalation involves insertion by covalent linkage of a molecule into the double-stranded deoxyribonucleotide polymer between the internal… 
National Institutes of Health

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4'-deoxy-4'-iododoxorubicinBi-functional Alkylating Agent VAL-083DNA Minor Groove Binding Agent SG2000EDO-S101

Papers overview

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2012
2012
Molecular mechanism of direct proflavine-DNA intercalation: evidence for drug-induced minimum base-stacking penalty pathway.
DNA intercalation, a biophysical process of enormous clinical significance, has surprisingly eluded molecular understanding for… 
2008
2008
Fabrication of DNA nanowires by orthogonal self-assembly and DNA intercalation on a Au patterned Si/SiO2 surface.
A novel Ru complex bearing both an acridine group and anchoring phosphonate groups was immobilized on a surface in order to… 
2004
2004
Evaluation of DNA intercalation potential of pharmaceuticals and other chemicals by cell‐based and three‐dimensional computational approaches
To what extent noncovalent chemical‐DNA interactions, in particular weak nonbonded DNA intercalation, contribute to genotoxic… 
2002
2002
EVIDENCE FOR AND ROLE OF THE DIMETHYLAMINO GROUP IN TAMOXIFEN DNA INTERCALATION IN INTACT CHINESE HAMSTER V79 CELLS
ABSTRACT The in vitro and in vivo genotoxicity of tamoxifen is well documented but the underlying mechanism of this genotoxicity… 
Highly Cited
2000
Highly Cited
2000
DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine.
Cryptolepine and neocryptolepine are two indoloquinoline alkaloids isolated from the roots of the African plant Cryptolepis… 
Highly Cited
1999
Highly Cited
1999
Electrostatic factors in DNA intercalation.
The factors that determine the binding of a chromophore between the base pairs in DNA intercalation complexes are dissected. The… 
1995
1995
Evanescent fluorobiosensor for the detection of polyaromatic hydrocarbon based on DNA intercalation
A flow-injection analysis (FIA) system coupled with an evanescent wave (EW) Biosensor employing total internal reflection of… 
1994
1994
Application of photochemical reaction in electrochemical detection of DNA intercalation.
A flow injection analysis (FIA) system for the detection of the compounds that intercalate within DNA is reported. A derivative… 
Highly Cited
1992
Highly Cited
1992
DNA intercalation and photosensitization by cationic meso substituted porphyrins.
Several cationic porphyrins are known to bind to DNA by intercalative and outside binding modes. This study identifies the cis… 
Highly Cited
1987
Highly Cited
1987
Viscosity dependence of ethidium-DNA intercalation kinetics.
The kinetics of ethidium intercalation into double-stranded poly[d(G-C)] were investigated by use of repetitive pressure-jump… 
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