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4,5-dioxovaleric acid

National Institutes of Health

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2002
2002
Genotoxicity of 5‐aminolevulinic and 4,5‐dioxovaleric acids in the salmonella/microsuspension mutagenicity assay and SOS chromotest
5‐Aminolevulinic acid (ALA) is a heme precursor that accumulates in some porphyric disorders and in lead poisoning which can… 
2000
2000
DNA damage by 5-aminolevulinic and 4,5-dioxovaleric acids in the presence of ferritin.
Cellular accumulation of 5-aminolevulinic acid (ALA), the first specific intermediate of heme biosynthesis, is correlated in… 
Review
1999
Review
1999
Purine DNA adducts of 4,5-dioxovaleric acid and 2,4-decadienal.
The present overview describes recent findings on the formation of cyclic adducts of purine DNA bases after reaction with two… 
Highly Cited
1998
Highly Cited
1998
DNA alkylation by 4,5-dioxovaleric acid, the final oxidation product of 5-aminolevulinic acid.
The heme precursor 5-aminolevulinic acid (ALA) accumulates under pathological conditions, namely, acute intermittent porphyria… 
Highly Cited
1992
Highly Cited
1992
Activity and spectroscopic properties of the Escherichia coli glutamate 1-semialdehyde aminotransferase and the putative active site mutant K265R.
Glutamate 1-semialdehyde aminotransferase (glutamate 1-semialdehyde 2,1-aminomutase; EC 5.4.3.8; GSA-AT) catalyzes the transfer… 
1992
1992
The enantioselective participation of (S)- and (R)-diaminovaleric acids in the formation of delta-aminolevulinic acid in cyanobacteria.
1985
1985
Heme synthesis in Crithidia deanei: influence of the endosymbiote.
1983
1983
Alternative Routes for the Synthesis of 5-Aminolevulinic Acid in Maize Leaves : I. Formation from 2-Ketoglutarate via 4,5-Dioxovaleric Acid.
Cell-free extracts from greening maize (Zea mays L.) leaves catalyze the conversion of [(14)C]2-ketoglutarate (KG) to [(14)C]5… 
1980
1980
The synthesis and properties of 4,5-dioxovaleric acid, a possible intermediate in the biosynthesis of 5-aminolaevulinic acid, and its in vivo formation in Scenedesmus obliquus.
1980
1980
Two biosynthetic pathways to 5-aminolevulinic acid in algae.
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