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Mitochondrial and nuclear DNA damage induced by 5-aminolevulinic acid.
Oxidative and alkylating damage in DNA.
DNA alkylation by 4,5-dioxovaleric acid, the final oxidation product of 5-aminolevulinic acid.
It is established that the final oxidation product of ALA, 4,5-dioxovaleric acid (DOVA), is an efficient alkylating agent of the guanine moieties within both nucleoside and isolated DNA.
5-Aminolevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2'-deoxyguanosine in DNA.
The hypothesis that ALA-generated reactive oxygen species can oxidize DNA and may be involved in the development of primary liver cell carcinoma in individuals with symptomatic acute intermittent porphyria is supported.
Inhibition of 5‐aminolevulinic acid‐induced DNA damage by melatonin, N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine, quercetin or resveratrol
The antioxidant efficacy of several compounds including melatonin, quercetin, resveratrol and N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK), a melatonin oxidation product, are shown in terms of their ability to limit DNA damage induced by ALA/Fe2+ in an in vitro system.
Association of microRNA‐34a overexpression with proliferation is cell type‐dependent
Results indicate that miRNA‐34a overexpression, an acquired trait during carcinogenesis, supports cell proliferation in the majority of cancers suggesting an unexpected link in the cellular metabolism between cancer and neuronal and/or endocrine cells, which warrants further investigation.
DNA damage by 5-aminolevulinic and 4,5-dioxovaleric acids in the presence of ferritin.
It was shown that ALA in the presence of ferritin is able to increase the oxidation of the guanine moiety of monomeric 2'-deoxyguanosine and calf thymus DNA to form 8-oxodGuo as inferred from high performance liquid chromatography (HPLC) measurements using electrochemical detection.