Oxidative stress in digestive gland and gill of the brown mussel (Perna perna) exposed to air and re-submersed
Biological hydroperoxides and singlet molecular oxygen generation
It is demonstrated that LOOH can originate 1O2 and is generated at a yield close to 10% by the Russell mechanism, where a linear tetraoxide intermediate is formed in the combination of two peroxyl radicals.
[13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells.
- C. C. M. Garcia, J. P. Angeli, M. Medeiros
- Chemistry, MedicineJournal of the American Chemical Society
- 27 May 2011
The unequivocal formation of 1,N(2)-propanodGuo in cells exposed to this aldehyde can be used to elucidate the mechanisms associated with acetaldehyde exposure and cancer risk.
Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen.
- A. U. Khan, P. Di Mascio, M. Medeiros, T. Wilson
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 December 1992
Oxidative damage to DNA induced by singlet molecular oxygen (1O2*) includes single-strand breaks, which the biologically occurring 1O2* quenchers spermine and spermidine are shown to prevent. These…
Singlet Molecular Oxygen Generation by Light-Activated DHN-Melanin of the Fungal Pathogen Mycosphaerella fijiensis in Black Sigatoka Disease of Bananas
The research shows that melanin synthesized by the fungal banana pathogen Mycosphaerella fijiensis acts as a virulence factor through the photogeneration of singlet molecular oxygen O2 (1Δg), a highly reactive oxygen specie that causes cellular death by reacting with all cellular macromolecules.
Singlet molecular oxygen production in the reaction of peroxynitrite with hydrogen peroxide
DNA damage by singlet oxygen and cellular protective mechanisms.
DNA alkylation by 4,5-dioxovaleric acid, the final oxidation product of 5-aminolevulinic acid.
- T. Douki, J. Onuki, M. Medeiros, E. Bechara, J. Cadet, P. Di Mascio
- Chemistry, BiologyChemical research in toxicology
- 31 January 1998
It is established that the final oxidation product of ALA, 4,5-dioxovaleric acid (DOVA), is an efficient alkylating agent of the guanine moieties within both nucleoside and isolated DNA.
Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins.
- P. Di Mascio, G. Martinez, S. Miyamoto, G. Ronsein, M. Medeiros, J. Cadet
- Chemistry, BiologyChemical Reviews
- 5 February 2019
Emphasis is placed in this Review on the description of the main oxidation reactions initiated by 1O2 and the resulting modifications within key cellular targets, including guanine for nucleic acids, unsaturated lipids, and targeted amino acids.
Singlet Oxygen Induces Oxidation of Cellular DNA*
- J. Ravanat, P. Di Mascio, G. Martinez, M. Medeiros, J. Cadet
- Chemistry, BiologyJournal of Biological Chemistry
- 22 December 2000
This result clearly demonstrates that singlet oxygen, when released within cells, is able to directly oxidize cellular DNA.