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3-deazaguanine

Known as: 6-aminoimidazo(4,5-c)pyridin-4(5H)-one, Deazaguanine, Dezaguanine 
A purine nucleoside analogue with antineoplastic and antiviral activities. By replacing guanine, dezaguanine incorporates into DNA and inhibits de… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

AntimetabolitesAntimetabolites, AntineoplasticGuanine

Narrower (1)

CI-908
Dezaguanine Mesylateanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate
DNA polymerase η (Polη) functions in the proficient bypass of a variety of DNA lesions. Relative to the replicative polymerases… 
Highly Cited
2001
Highly Cited
2001
Identification of hydrogen bonds between Escherichia coli DNA polymerase I (Klenow fragment) and the minor groove of DNA by amino acid substitution of the polymerase and atomic substitution of the…
DNA polymerases replicate DNA with high fidelity despite the small differences in energy between correct and incorrect base pairs… 
1990
1990
The deazaguanine‐derivative, queuine, affects cell proliferation, protein phosphorylation and the expression of the proto oncogenes c‐fos and c‐myc in HeLa cells
1984
1984
Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides.
A new procedure for the preparation of the antiviral and antitumor agent 3-deazaguanine (1) and its metabolite 3-deazaguanosine… 
1983
1983
synthesis and antitumor activity of 2-deoxyribofuranosides of 3-deazaguanine.
Synthesis of 2-deoxyribofuranosides of 3-deazaguanine (IX-XII) has been achieved by a base-catalyzed ring closure of appropriate… 
1982
1982
3-Deazaguanine: inhibition of initiation of translation in L1210 cells.
In L1210 cells in culture, 3-deazaguanine (DG), a relatively new purine analog, was found to inhibit DNA and protein synthesis… 
1982
1982
3-deazaguanine, a candidate drug for the chemotherapy of breast carcinomas?
: 3-Deazaguanine (3-DG) is a new purine antagonist that is active against slow- and rapid-growing solid experimental tumors… 
1979
1979
Synthesis of arabinofuranosyl derivatives of 3-deazaguanine.
Synthesis of four arabinofuranosyl derivatives of the antitumor agent 3-deazaguanine is described. By the use of 13C and 1H… 
Highly Cited
1976
Highly Cited
1976
Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors.
1957
1957
Deazapurines as growth inhibitors.
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