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3-deazaguanine

Known as: 6-aminoimidazo(4,5-c)pyridin-4(5H)-one, Deazaguanine, Dezaguanine 
A purine nucleoside analogue with antineoplastic and antiviral activities. By replacing guanine, dezaguanine incorporates into DNA and inhibits de… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

AntimetabolitesAntimetabolites, AntineoplasticGuanine

Narrower (1)

CI-908
Dezaguanine Mesylateanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Synthesis of 2′-O-methyl-RNAs incorporating a 3-deazaguanine, and UV melting and computational studies on its hybridization properties
2′-O-Methyl-RNAs incorporating 3-deazaguanine (c3G) were synthesized by use of N,N-diphenylcarbamoyl and N,N… 
1996
1996
Defective transfer RNA-queuine modification in C3H10T1/2 murine fibroblasts transfected with oncogenic ras.
tRNA isoacceptors for aspartic acid, asparagine, histidine, and tyrosine are modified in the anticodon wobble position with the… 
1988
1988
DNA-directed actions of 3-deazaguanine: effects on DNA integrity and DNA elongation/ligation.
The cytotoxic action of the guanine analogue, 3-deazaguanine, was shown previously to be closely associated with deazaguanine… 
1986
1986
Correlation of biochemical effects and incorporation of 3-deazaguanine into nucleic acids to cytotoxicity in L1210 cells.
3-Deazaguanine, a tumor-inhibitory purine antimetabolite, is cytotoxic to L1210 leukemic cells in culture. The log percentage of… 
1985
1985
Differential turnover of tRNAs of the queuosine family in Dictyostelium discoideum and its possible role in regulation.
In its natural environment the protist Dictyostelium discoideum grows on bacteria and queuosine-containing tRNAs of the bacteria… 
1984
1984
Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides.
A new procedure for the preparation of the antiviral and antitumor agent 3-deazaguanine (1) and its metabolite 3-deazaguanosine… 
1983
1983
synthesis and antitumor activity of 2-deoxyribofuranosides of 3-deazaguanine.
Synthesis of 2-deoxyribofuranosides of 3-deazaguanine (IX-XII) has been achieved by a base-catalyzed ring closure of appropriate… 
1982
1982
3-deazaguanine, a candidate drug for the chemotherapy of breast carcinomas?
: 3-Deazaguanine (3-DG) is a new purine antagonist that is active against slow- and rapid-growing solid experimental tumors… 
1979
1979
Synthesis of arabinofuranosyl derivatives of 3-deazaguanine.
Synthesis of four arabinofuranosyl derivatives of the antitumor agent 3-deazaguanine is described. By the use of 13C and 1H… 
Highly Cited
1976
Highly Cited
1976
Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors.
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