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Cloning and characterization of a human angiotensin II type 1 receptor.
A human liver cDNA library was screened using a rat type 1 angiotensin II receptor cDNA coding sequence as a probe. cDNA clones were isolated which encoded a protein of 359 amino acids that sharedExpand
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The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.
Cyclophilin (CyP), a major cytosolic protein possessing peptidyl-prolyl cis-trans isomerase activity, has been implicated as the specific receptor of the immunosuppressive drug cyclosporin A (CsA).Expand
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Action of Nucleic Acids on the Inhibition of Growth by Actinomycin of Neurospora crassa
ACTINOMYCIN is well known to possess cytostatic properties in mammalian tissues1. Foley et al.2 have shown the inhibitory effect of actinomycin on the cell-growth of 12 microbiological systems underExpand
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Chapter 2 Biosynthesis and Function of Queuine and Queuosine tRNAs
Publisher Summary This chapter investigates the biosynthesis of queuosine and the occurrence of Q or G at position 34 in transfer RNA (tRNA) Asn , tRNA Asp , tRNA His , and tRNA Tyr from eubacteriaExpand
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The nutrient factor queuine protects HeLa cells from hypoxic stress and improves metabolic adaptation to oxygen availability.
Queuine (q), a cyclopentendiol derivative of 7-aminomethyl-7-deazaguanine, is a nutrient factor for lower and higher eukaryotes, except yeast; it is synthesized in eubacteria partly at the level ofExpand
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Inhibitors of nucleic acid synthesis: biophysical and biochemical aspects.
General Introduction.- I. Inhibitors of DNA Synthesis.- A. Mitomycin.- 1. Origin, Biological and Chemical Properties.- 2. On the Molecular Mechanism of Action.- a) Interaction with DNA in Vitro.- b)Expand
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Role of ribothymidine in the thermal stability of transfer RNA as monitored by proton magnetic resonance.
In order to elucidate the functional role of the modified uridines at position 54 of tRNA, the 270 MHz high-field proton NMR spectra of methionine tRNAs from E. coli, from a mutant thereof, and fromExpand
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New function of vitamin B12: cobamide-dependent reduction of epoxyqueuosine to queuosine in tRNAs of Escherichia coli and Salmonella typhimurium.
Queuosine (Q), 7-[(4,5-cis-dihydroxy-2-cyclopentene-1-yl)-amino)methyl)-7- deazaguanosine, and Q derivatives usually replace guanosine in the anticodon of tRNAs(GUN) of eubacteria and of cytoplasmicExpand
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Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes.
The plasmid pPR20 contains the gene tgt, which encodes tRNA guanine transglycosylase (Tgt), on a 33-kbp DNA insert from a region around 9 min on the Escherichia coli linkage map. The plasmid wasExpand
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A new function of S-adenosylmethionine: the ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine.
Queuosine (Q) [7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deaz agu anosine] usually occurs in the first position of the anticodon of tRNAs specifying the amino acids asparagine,Expand
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