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3-chlorotyrosine

Known as: L-(8CI)-3-Chloro-Tyrosine, Cl-Tyr, Monochlorotyrosine 
A specific biomarker of hypochlorous acid (HClO), the oxidation product of myeloperoxidase (MPO). Under oxidative stress, 3-chlorotyrosine is… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Enzyme InhibitorsTyrosine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Measuring chlorine bleach in biology and medicine.
Highly Cited
2013
Highly Cited
2013
Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.
Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein-associated (HDL-associated) proteins mechanistically… 
Highly Cited
2003
Highly Cited
2003
3-Chlorotyrosine as a Marker of Protein Damage by Myeloperoxidase in Tracheal Aspirates From Preterm Infants: Association With Adverse Respiratory Outcome
Oxidative injury is implicated in the development of chronic lung disease in preterm infants with respiratory distress. However… 
Highly Cited
2002
Highly Cited
2002
Elevated Free Radical Products in the Cerebrospinal Fluid of VLBW Infants with Cerebral White Matter Injury
Free radical mediated cellular injury has been hypothesized to play a key role in the pathogenesis of white matter injury in the… 
Highly Cited
2001
Highly Cited
2001
alpha(2)-Macroglobulin from rheumatoid arthritis synovial fluid: functional analysis defines a role for oxidation in inflammation.
A hallmark of inflammation is the release of oxidants, proteinases, and cytokines, all important mediators of the inflammatory… 
Highly Cited
1999
Highly Cited
1999
Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination.
OBJECTIVE To assess the degree, source, and patterns of oxidative damage to bronchoalveolar lavage proteins as a modification of… 
Highly Cited
1998
Highly Cited
1998
Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA.
Highly Cited
1996
Highly Cited
1996
Neutrophils convert tyrosyl residues in albumin to chlorotyrosine
Highly Cited
1996
Highly Cited
1996
Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid
Detection of 3-nitrotyrosine has served as an in vivo marker for the production of the cytotoxic species peroxynitrite (ONOO… 
Highly Cited
1995
Highly Cited
1995
Chlorination of Tyrosyl Residues in Peptides by Myeloperoxidase and Human Neutrophils (*)
Hypochlorous acid is the major strong oxidant generated by human neutrophils, and it has the potential to cause much of the… 
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