• Publications
  • Influence
Taurine and inflammatory diseases
Taurine (2-aminoethanesulfonic acid) is the most abundant free amino acid in humans and plays an important role in several essential biological processes such as bile acid conjugation, maintenance ofExpand
  • 233
  • 12
  • PDF
Taurine chloramine down-regulates the generation of murine neutrophil inflammatory mediators.
We previously reported that taurine chloramine (TauCl), a product of activated neutrophils, inhibits the generation of macrophage inflammatory mediators such as nitric oxide (NO), TNF-alpha, andExpand
  • 91
  • 6
Neutrophil Myeloperoxidase: Soldier and Statesman
Myeloperoxidase (MPO) is a major protein constituent of the primary granules of vertebrate neutrophils. It catalyses the hydrogen peroxide-mediated oxidation of halide ions to hypohalous acids,Expand
  • 86
  • 5
Nitric oxide up‐regulates the release of inflammatory mediators by mouse macrophages
Nitric oxide (NO) plays a key role in mediating macrophage cytotoxicity towards different targets, including tumoral cells and intracellular pathogens. However, its role in macrophageExpand
  • 132
  • 4
Antimicrobial and cytotoxic activity of hypochlorous acid: interactions with taurine and nitrite
Objective. HOCl, a major bactericidal product of neutrophil MPO - halide system reacts with taurine to form taurine chloramine (TauCl), a less toxic anti-inflammatory mediator. Recently, it has beenExpand
  • 69
  • 4
Taurine chloramine modulates cytokine production by human peripheral blood mononuclear cells
Summary. The effect of taurine (Tau) and taurine chloramine (Tau-Cl) on the production of TNF-α, IL-1β, and IL-6 by peripheral blood mononuclear cells of healthy volunteers was examined. Cells wereExpand
  • 51
  • 4
Human monocytes are stimulated for nitric oxide release in vitro by some tumor cells but not by cytokines and lipopolysaccharide
Nitric oxide (NO) has been recently identified as a potent mediator of tumoricidal activity of activated macrophages. Macrophages can be activated for tumor cell killing by microbial products,Expand
  • 120
  • 3
Regulation of murine dendritic cell functions in vitro by taurine chloramine, a major product of the neutrophil myeloperoxidase–halide system
Taurine chloramine (TauCl) is a major chloramine generated in activated neutrophils as a result of the reaction of highly toxic hypochlorous acid and taurine, the most abundant free amino acid inExpand
  • 67
  • 3
Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide
Abstract.Objective and Design: The myeloperoxidase system of neutrophils generates chlorinating and brominating oxidants in vivo. The major haloamines of the system are taurine chloramine (TauCl) andExpand
  • 39
  • 3
Leukotrienes modulate cytokine release from dendritic cells
Leukotriene B4 (LTB4) and cysteinyl leukotrienes (CysLTs) are known as potent mediators of inflammation, whereas their role in the regulation of adaptive immunity remains poorly characterized.Expand
  • 44
  • 3