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3,15,17-trihydroxypregnan-20-one

Known as: 3 alpha,15 beta,17 alpha-trihydroxy-5 beta-pregnan-20-one, 3,15,17-TH-5P, 3,15,17-trihydoxy-5alpha-pregnan-20-one 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Pregnanetriol
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.
The crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)/bile acid binding protein (AKR1C2) complexed… Expand
Highly Cited
2000
Highly Cited
2000
Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol
Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide… Expand
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Highly Cited
2000
Highly Cited
2000
Neurosteroid Modulation of GABA IPSCs Is Phosphorylation Dependent
The neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) facilitates GABAAreceptor-mediated ionic currents via allosteric… Expand
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Highly Cited
1999
Highly Cited
1999
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.
The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of gamma… Expand
Highly Cited
1999
Highly Cited
1999
Sex and Estrous Cycle-Dependent Changes in Neurosteroid and Benzodiazepine Effects on Food Consumption and Plus-Maze Learning Behaviors in Rats
Experiments were designed to investigate the influence of estrous cycle and gender of the rat on the effects of a gamma… Expand
Highly Cited
1997
Highly Cited
1997
Characterization of the anticonvulsant properties of Ganaxolone (CCD 1042; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high-affinity, steroid modulator of the γ-aminobutyric acid(A…
Ganaxolone (CCD 1042) is a 3b-methyl-substituted analog of the endogenous neuroactive steroid 3a-hydroxy-5a-pregnan20-one… Expand
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Highly Cited
1997
Highly Cited
1997
Neurosteroid Prolongs GABAA Channel Deactivation by Altering Kinetics of Desensitized States
Fast applications of GABA (1 mm) to nucleated and outside-out patches excised from granule neurons in cerebellar slices from… Expand
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1997
1997
Use of a radioimmunoassay which detects C21 steroids with a 5beta-reduced, 3alpha-hydroxylated configuration to identify and measure steroids involved in final oocyte maturation in female plaice…
Two radioimmunoassays (RIAs) have been developed which detect C21 (pregnane) steroids with a 5beta-reduced, 3alpha-hydroxyl… Expand
1971
1971
In vivo production of steroids with central depressant actions by the ovary of the rat
  • M. Holzbauer
  • British journal of pharmacology
  • 1971
    • Corpus ID: 23553701
1 In addition to progesterone and 20‐dihydroprogesterone, the following unconjugated steroids were isolated from ovarian tissue… Expand
1961
1961
The Metabolism of 4-C14-Testosterone in Rat Testis Homogenate
The biosynthetic capacity of the testis has been well documented in recent years. Some evidence is available that this organ does… Expand
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