3,15,17-trihydroxypregnan-20-one

Known as: 3 alpha,15 beta,17 alpha-trihydroxy-5 beta-pregnan-20-one, 3,15,17-TH-5P, 3,15,17-trihydoxy-5alpha-pregnan-20-one 
 
National Institutes of Health

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2 relations

Broader (1)

Pregnanetriol
analogs & derivatives

Papers overview

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2001
2001
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.
The crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)/bile acid binding protein (AKR1C2) complexed… Expand
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2001
2001
3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex.
Despite considerable evidence showing dramatic changes in the plasticity of GABA(A) receptors during neuronal development and… Expand
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2001
2001
Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.
Pregnenolone sulphate (PREGS) has generated interest as one of the most potent memory-enhancing neurosteroids to be examined in… Expand
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Highly Cited
2000
Highly Cited
2000
Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol
Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide… Expand
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Highly Cited
2000
Highly Cited
2000
Neurosteroid modulation of GABA IPSCs is phosphorylation dependent.
The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) facilitates GABA(A) receptor-mediated ionic currents via… Expand
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Highly Cited
1999
Highly Cited
1999
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.
The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of gamma… Expand
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1999
1999
Sex and Estrous Cycle-Dependent Changes in Neurosteroid and Benzodiazepine Effects on Food Consumption and Plus-Maze Learning Behaviors in Rats
Experiments were designed to investigate the influence of estrous cycle and gender of the rat on the effects of a gamma… Expand
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1998
1998
Transient Expression of the 5α-Reductase Type 2 Isozyme in the Rat Brain in Late Fetal and Early Postnatal Life.
The enzyme 5α-reductase plays a key role on several brain functions controlling the formation of anxiolytic/anesthetic steroids… Expand
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Highly Cited
1997
Highly Cited
1997
Neurosteroid prolongs GABAA channel deactivation by altering kinetics of desensitized states.
Fast applications of GABA (1 mM) to nucleated and outside-out patches excised from granule neurons in cerebellar slices from… Expand
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Highly Cited
1997
Highly Cited
1997
Characterization of the Anticonvulsant Properties of Ganaxolone (CCD 1042; 3a-Hydroxy-3b-methyl-5a-pregnan- 20-one), a Selective, High-Affinity, Steroid Modulator of the g-Aminobutyric Acid A…
Ganaxolone (CCD 1042) is a 3b-methyl-substituted analog of the endogenous neuroactive steroid 3a-hydroxy-5a-pregnan20-one… Expand
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