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3,15,17-trihydroxypregnan-20-one

Known as: 3 alpha,15 beta,17 alpha-trihydroxy-5 beta-pregnan-20-one, 3,15,17-TH-5P, 3,15,17-trihydoxy-5alpha-pregnan-20-one 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Pregnanetriol
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.
The crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)/bile acid binding protein (AKR1C2) complexed… 
Highly Cited
2000
Highly Cited
2000
Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol
Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide… 
Highly Cited
2000
Highly Cited
2000
Neurosteroid Modulation of GABA IPSCs Is Phosphorylation Dependent
The neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) facilitates GABAAreceptor-mediated ionic currents via allosteric… 
Highly Cited
1999
Highly Cited
1999
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.
The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of gamma… 
Highly Cited
1999
Highly Cited
1999
Sex and Estrous Cycle-Dependent Changes in Neurosteroid and Benzodiazepine Effects on Food Consumption and Plus-Maze Learning Behaviors in Rats
Highly Cited
1997
Highly Cited
1997
Characterization of the anticonvulsant properties of Ganaxolone (CCD 1042; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high-affinity, steroid modulator of the γ-aminobutyric acid(A…
Ganaxolone (CCD 1042) is a 3b-methyl-substituted analog of the endogenous neuroactive steroid 3a-hydroxy-5a-pregnan20-one… 
Highly Cited
1997
Highly Cited
1997
Neurosteroid Prolongs GABAA Channel Deactivation by Altering Kinetics of Desensitized States
Fast applications of GABA (1 mm) to nucleated and outside-out patches excised from granule neurons in cerebellar slices from… 
1997
1997
Use of a radioimmunoassay which detects C21 steroids with a 5beta-reduced, 3alpha-hydroxylated configuration to identify and measure steroids involved in final oocyte maturation in female plaice…
Two radioimmunoassays (RIAs) have been developed which detect C21 (pregnane) steroids with a 5beta-reduced, 3alpha-hydroxyl… 
1971
1971
In vivo production of steroids with central depressant actions by the ovary of the rat
  • M. Holzbauer
  • British journal of pharmacology
  • 1971
  • Corpus ID: 23553701
1 In addition to progesterone and 20‐dihydroprogesterone, the following unconjugated steroids were isolated from ovarian tissue… 
1961
1961
The Metabolism of 4-C14-Testosterone in Rat Testis Homogenate
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