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3,15,17-trihydroxypregnan-20-one

Known as: 3 alpha,15 beta,17 alpha-trihydroxy-5 beta-pregnan-20-one, 3,15,17-TH-5P, 3,15,17-trihydoxy-5alpha-pregnan-20-one 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Pregnanetriol
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Steroid structure and pharmacological properties determine the anti‐amnesic effects of pregnenolone sulphate in the passive avoidance task in rats
Pregnenolone sulphate (PREGS) has generated interest as one of the most potent memory‐enhancing neurosteroids to be examined in… 
2001
2001
3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex.
Despite considerable evidence showing dramatic changes in the plasticity of GABA(A) receptors during neuronal development and… 
Highly Cited
2000
Highly Cited
2000
Neurosteroid Modulation of GABA IPSCs Is Phosphorylation Dependent
The neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) facilitates GABAAreceptor-mediated ionic currents via allosteric… 
Highly Cited
1997
Highly Cited
1997
Neurosteroid Prolongs GABAA Channel Deactivation by Altering Kinetics of Desensitized States
Fast applications of GABA (1 mm) to nucleated and outside-out patches excised from granule neurons in cerebellar slices from… 
1997
1997
Use of a radioimmunoassay which detects C21 steroids with a 5beta-reduced, 3alpha-hydroxylated configuration to identify and measure steroids involved in final oocyte maturation in female plaice…
Two radioimmunoassays (RIAs) have been developed which detect C21 (pregnane) steroids with a 5beta-reduced, 3alpha-hydroxyl… 
1997
1997
Partial agonism by 3alpha,21-dihydroxy-5beta-pregnan-20-one at the gamma-aminobutyric acidA receptor neurosteroid site.
3alpha,21-Dihydroxy-5alpha-pregnan-20-one (5alpha-THDOC) and 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-P) have full… 
1993
1993
New identified 15β-hydroxylated 21-deoxy-pregnanes in congenital adrenal hyperplasia due to 21-hydroxylase deficiency
1980
1980
The early recognition of the 21-hydroxylase deficiency variety of congenital adrenal hyperplasia.
1973
1973
Female Pattern of Metabolism of [4-14C]Corticosterone in Male Pseudohermaphroditic Rats
Summary The metabolites of [4-14C]corticosterone appearing in bile fistulae of male pseudohermaphrodites and littermate male and… 
1961
1961
The Metabolism of 4-C14-Testosterone in Rat Testis Homogenate
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