3,15,17-trihydroxypregnan-20-one

Known as: 3 alpha,15 beta,17 alpha-trihydroxy-5 beta-pregnan-20-one, 3,15,17-TH-5P, 3,15,17-trihydoxy-5alpha-pregnan-20-one 
 
National Institutes of Health

Papers overview

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2001
2001
The crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)/bile acid binding protein (AKR1C2) complexed… Expand
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2001
2001
Despite considerable evidence showing dramatic changes in the plasticity of GABA(A) receptors during neuronal development and… Expand
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2001
2001
Pregnenolone sulphate (PREGS) has generated interest as one of the most potent memory-enhancing neurosteroids to be examined in… Expand
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Highly Cited
2000
Highly Cited
2000
Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide… Expand
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Highly Cited
2000
Highly Cited
2000
The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) facilitates GABA(A) receptor-mediated ionic currents via… Expand
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Highly Cited
1999
Highly Cited
1999
The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of gamma… Expand
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1999
1999
Experiments were designed to investigate the influence of estrous cycle and gender of the rat on the effects of a gamma… Expand
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1998
1998
The enzyme 5α-reductase plays a key role on several brain functions controlling the formation of anxiolytic/anesthetic steroids… Expand
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Highly Cited
1997
Highly Cited
1997
Fast applications of GABA (1 mM) to nucleated and outside-out patches excised from granule neurons in cerebellar slices from… Expand
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Highly Cited
1997
Highly Cited
1997
Ganaxolone (CCD 1042) is a 3b-methyl-substituted analog of the endogenous neuroactive steroid 3a-hydroxy-5a-pregnan20-one… Expand
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