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Design and in vitro pharmacology of a selective gamma-aminobutyric acidC receptor antagonist.
TLDR
(1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA), a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors, is reported.
Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys.
TLDR
The data suggest that the NR2 subunit selectivity profile of NMDA receptor antagonists can play an important role in predicting behavioral outcome and offer more evidence that NR2B-selective NMda receptor antagonists may be useful agents in the treatment of Parkinson's disease.
Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric
TLDR
The pharmacological profile of these rho-like receptors was extended by measuring sensitivities to various GABAA and GABAB receptor ligands, with bicuculline/baclofen-insensitive gamma-aminobutyric acid (GABA) receptors in Xenopus oocytes with properties similar to those of homooligomeric GABA rho 1 receptors.
Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.
TLDR
The results argue that antagonism of NMDA receptor currents by the sigma ligands tested is due to direct effects on the receptor channel complex as opposed to indirect effects mediated by sigma receptors.
Effects of defolliculation on membrane current responses of Xenopus oocytes.
TLDR
These experiments suggest that cyclic nucleotide‐activated K+ currents arise essentially in follicular cells and are monitored within the oocyte through electrical coupling by gap junctions, and are produced largely or wholly in the oocytes itself.
Effects of fenamates and other nonsteroidal anti-inflammatory drugs on rat brain GABAA receptors expressed in Xenopus oocytes.
TLDR
It is raised that fenamates could serve as lead structures in the development of novel GABAA receptor modulators and that fensamates might affect GabAA receptor function at a normal clinical dosage.
Effects of steroids on gamma-aminobutyric acid receptors expressed in Xenopus oocytes by poly(A)+ RNA from mammalian brain and retina.
TLDR
Electrical recordings were made in Xenopus oocytes to study the modulatory effects of steroids on gamma-aminobutyric acid (GABA) receptors expressed by RNA from mammalian brain and retina, and GABAA responses expressed in oocytes by cerebral cortex RNA were strongly and stereospecifically potentiated by 3 alpha-OH-DHP and THDOC.
Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.
TLDR
The results suggest that haloperidol can be used as a tool for investigating NMDA receptor subunit composition and can serve as a structural lead for designing novel subtype-selectiveNMDA receptor ligands.
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