Skip to search formSkip to main contentSkip to account menu

3,4-Dihydroxyphenylacetic Acid

Known as: DOPAC, 3,4 Dihydroxyphenylacetic Acid, dihydroxyphenylacetic acid 
A deaminated metabolite of LEVODOPA.
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (3)

(4-hydroxy-3-methoxyphenyl)acetaldehyde3,4-Dihydroxyphenylacetate3,4-dihydroxyphenylacetaldehyde

Broader (2)

AcidsPhenylacetates
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity.
Dietary flavonoids are poorly absorbed from the gastrointestinal tract. Colonic bacteria convert flavonoids into smaller phenolic… 
Highly Cited
2004
Highly Cited
2004
Dopaminergic Differentiation of Human Embryonic Stem Cells
In this manuscript we report that human embryonic stem cells (hESCs) differentiated into dopaminergic neurons when cocultured… 
Highly Cited
2000
Highly Cited
2000
The Nigrostriatal Dopaminergic System as a Preferential Target of Repeated Exposures to Combined Paraquat and Maneb: Implications for Parkinson's Disease
Experimental evidence supporting 1,1′-dimethyl-4,4′-bipyridinium [paraquat (PQ)] as a risk factor for Parkinson's disease (PD) is… 
Highly Cited
1992
Highly Cited
1992
Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion.
Extracellular concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA… 
Highly Cited
1989
Highly Cited
1989
Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis
The temporal and dose-related behavioral and striatal monoamine response to amphetamine (AMPH) was examined using in vivo… 
Highly Cited
1988
Highly Cited
1988
In vivo measurement of extracellular dopamine and DOPAC in rat striatum after various dopamine-releasing drugs; implications for the origin of extracellular DOPAC.
Highly Cited
1986
Highly Cited
1986
Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.
The effect of the i.p. administration of ethanol on the release of dopamine (DA) and on the output of its main metabolites… 
Highly Cited
1983
Highly Cited
1983
In Vivo Measurement of Dopamine and Its Metabolites by Intracerebral Dialysis: Changes After d‐Amphetamine
Abstract: By using a new technique, intracerebral dialysis, in combination with high performance liquid chromatography and… 
Highly Cited
1982
Highly Cited
1982
Simultaneous Determination of 3,4‐Dihydroxyphenylalanine, 5‐Hydroxytryptophan, Dopamine, 4‐Hydroxy‐3‐Methoxyphenylalanine, Norepinephrine, 3,4‐Dihydroxyphenylacetic Acid, Homovanillic Acid, Serotonin…
Abstract: A method using reversed‐phase ion‐pair high‐performance liquid chromatography with electrochemical detection for the… 
Highly Cited
1982
Highly Cited
1982
Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)