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APLN gene

Known as: APJ RECEPTOR LIGAND, APLN, XNPEP2 
This gene is involved in the regulation of both immune responses and HIV-1 infection.
National Institutes of Health

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APLN wt Allele
ApelinImmune responseIntercellular Communication Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: A systematic review.
Highly Cited
2014
Highly Cited
2014
Apelin inhibits the proliferation and migration of rat PASMCs via the activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia
Apelin is highly expressed in the lungs, especially in the pulmonary vasculature, but the functional role of apelin under… 
Highly Cited
2013
Highly Cited
2013
Goldfish spexin: solution structure and novel function as a satiety factor in feeding control.
Spexin (SPX) is a neuropeptide identified recently by bioinformatic approach. At present not much is known about its biological… 
Highly Cited
2013
Highly Cited
2013
The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans‐inhibition
The apelin receptor (APJ) is often co‐expressed with the angiotensin II type‐1 receptor (AT1) and acts as an endogenous counter… 
Review
2010
Review
2010
Brain and cardiovascular diseases: common neurogenic background of cardiovascular, metabolic and inflammatory diseases.
In spite of significant progress in pharmacotherapy the incidence of newly diagnosed cases of cardiovascular diseases and… 
Highly Cited
2008
Highly Cited
2008
Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus.
OBJECTIVE To investigate blood apelin concentrations in patients with newly diagnosed and untreated type 2 diabetes mellitus… 
Highly Cited
2007
Highly Cited
2007
The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors.
Highly Cited
2007
Highly Cited
2007
Apelin and its receptor control heart field formation during zebrafish gastrulation.
Highly Cited
2006
Highly Cited
2006
Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-angiotensin type 1 receptor system.
Review
2006
Review
2006
Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity?
Recent studies suggest that adipose tissue hormones ("adipokines") are involved in the pathogenesis of various complications of… 
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