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Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis.
It is suggested that multiple signaling pathways are independently activated in the mid brain-hindbrain boundary primordium during gastrulation, and that Fgf8 functions later during somitogenesis to polarize the midbrain.
miR-126 regulates angiogenic signaling and vascular integrity.
Vertebrate Smoothened functions at the primary cilium
- K. Corbit, P. Aanstad, Veena Singla, Andrew R. Norman, D. Stainier, J. Reiter
- 13 October 2005
It is shown that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium, and Hh-dependent translocation to cilia is essential for Smo activity, suggesting that Smo acts at thePrimary cilia.
The perivascular niche regulates breast tumor dormancy
It is revealed that stable microvasculature constitutes a dormant niche, whereas sprouting neovasculature sparks micrometastatic outgrowth, which is a surprising result in dormancy models and in zebrafish.
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
The results indicate that electrically coupled cardiac muscle regenerates after resection injury, primarily through activation and expansion of cardiomyocyte populations, which have implications for promoting regeneration of the injured human heart.
The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins
A draft of the protein-coding portion of the genome of the most studied ascidian, Ciona intestinalis, is generated, suggesting that ascidians contain the basic ancestral complement of genes involved in cell signaling and development.
Hematopoietic stem cells derive directly from aortic endothelium during development
- Julien Y. Bertrand, N. Chi, B. Santoso, Shutian Teng, D. Stainier, D. Traver
- 31 December 2009
The unique strengths of the zebrafish embryo are used to image directly the generation of HSCs from the ventral wall of the dorsal aorta and it is demonstrated that the H SCs generated from haemogenic endothelium are the lineal founders of the adult haematopoietic system.
Cellular and molecular analyses of vascular tube and lumen formation in zebrafish
These studies provide the tools and a cellular framework for the investigation of mutations affecting vasculogenesis in zebrafish and indicate that the endoderm, a tissue previously implicated in vascular development, provides a substratum for endothelial cell migration and is involved in regulating the timing of this process, but that it is not essential for the direction of migration.
Cardiac troponin T is essential in sarcomere assembly and cardiac contractility
- A. Sehnert, Anja Huq, B. Weinstein, C. Walker, M. Fishman, D. Stainier
- BiologyNature Genetics
- 22 April 2002
It is postulated that some mutations in tnnt2 may trigger misregulation of thin-filament protein expression, resulting in sarcomere loss and myocyte disarray, the life-threatening hallmarks of TNNT2 mutations in mice and humans.
Molecular control of endothelial cell behaviour during blood vessel morphogenesis
These emerging frameworks controlling angiogenesis provide unique insights into fundamental biological processes common to other systems, such as tissue branching morphogenesis, mechanotransduction and tubulogenesis.