Apelin

Known as: AGTRL1 Ligand, APJ Endogenous Ligand, APLN 
Apelin (77 aa, ~9 kDa) is encoded by the human APLN gene. This protein is involved in both the inhibition of HIV-1 entry into cells and in immune… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The recently discovered peptide apelin is known to be involved in the maintenance of insulin sensitivity. However, questions… (More)
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Highly Cited
2009
Highly Cited
2009
Apelin receptors, present on vascular smooth muscle cells, endothelium, and cardiomyocytes, are activated by the family of apelin… (More)
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Highly Cited
2009
Highly Cited
2009
Apelin, the endogenous ligand of the G protein-coupled APJ receptor, is a peptide mediator with emerging regulatory actions in… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES This study was designed to establish the direct vascular effects of apelin in vivo in man. BACKGROUND Apelin is the… (More)
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Highly Cited
2008
Highly Cited
2008
Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and potentially link obesity to insulin… (More)
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Highly Cited
2005
Highly Cited
2005
The results presented herein demonstrate that apelin is expressed and secreted by both human and mouse adipocytes. Apelin mRNA… (More)
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Highly Cited
2004
Highly Cited
2004
There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled… (More)
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Highly Cited
2002
Highly Cited
2002
The orphan receptor APJ and its recently identified endogenous ligand, apelin, exhibit high levels of mRNA expression in the… (More)
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Highly Cited
2001
Highly Cited
2001
We analyzed the tissue distribution of apelin mRNA in rats by a quantitative reverse transcription-polymerase chain reaction and… (More)
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Highly Cited
2000
Highly Cited
2000
The apelin peptide was recently discovered and demonstrated to be the endogenous ligand for the G protein-coupled receptor, APJ… (More)
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