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Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
Embryonic morphogenesis is driven by a suite of cell behaviours, including coordinated shape changes, cellular rearrangements and individual cell migrations, whose molecular determinants are largelyExpand
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.
In vertebrate embryos, formation of anterior neural structures requires suppression of Wnt signals emanating from the paraxial mesoderm and midbrain territory. In Six3(-/-) mice, the prosencephalonExpand
Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function.
The zebrafish pronephric kidney provides a simplified model of nephron development and epithelial cell differentiation which is amenable to genetic analysis. The pronephros consists of two nephronsExpand
The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension.
Mutations in the zebrafish knypek locus impair gastrulation movements of convergent extension that narrow embryonic body and elongate it from head to tail. We demonstrate that knypek regulatesExpand
Zebrafish Rho Kinase 2 Acts Downstream of Wnt11 to Mediate Cell Polarity and Effective Convergence and Extension Movements
BACKGROUND During vertebrate gastrulation convergence and extension (CE), movements narrow and lengthen embryonic tissues. In Xenopus and zebrafish, a noncanonical Wnt signaling pathway constitutesExpand
Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling
Zebrafish cyclops (cyc) mutations cause deficiencies in the dorsal mesendoderm, and ventral neural tube,, leading to neural defects and cyclopia,. Here we report that cyc encodes a transformingExpand
Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity.
Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- andExpand
A genetic screen for mutations affecting embryogenesis in zebrafish.
Systematic genome-wide mutagenesis screens for embryonic phenotypes have been instrumental in the understanding of invertebrate and plant development. Here, we report the results from the firstExpand
Microtubule arrays of the zebrafish yolk cell: organization and function during epiboly.
In zebrafish (Danio rerio), meroblastic cleavages generate an embryo in which blastomeres cover the animal pole of a large yolk cell. At the 500-1000 cell stage, the marginal blastomeres fuse withExpand
Bmp activity gradient regulates convergent extension during zebrafish gastrulation.
During vertebrate gastrulation, a ventral to dorsal gradient of bone morphogenetic protein (Bmp) activity establishes cell fates. Concomitantly, convergent extension movements narrow germ layersExpand