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Different types of genetic technologies and approaches allow for the study and identification of different types of genetic… Expand Androgen signaling facilitates the formation of an oncogenic fusion gene in prostate cancer cells. Gene fusions play a critical… Expand Prostate cancer is a common and clinically heterogeneous disease with marked variability in progression. The recent… Expand Among the various phenotypes seen in Down syndrome (DS), mental retardation is the most common and most debilitating condition… Expand Down syndrome (DS), a major cause of mental retardation, is characterized by subtle abnormalities of cortical neuroanatomy… Expand Using Down syndrome as a model for complex trait analysis, we sought to identify loci from chromosome 21q22.2 which, when present… Expand The presence of an extra copy of human chromosome 21 (trisomy 21), especially region 21q22.2, causes many phenotypes in Down… Expand We identified and cloned a novel 9,078-bp cDNA, designated TPRDI, from the Down syndrome-critical region by exon trapping. The… Expand Libraries of the entire human genome, or regions of the genome, have been made in bacteria, yeast, and somatic cells. We have… Expand The duplication of a specific region of chromosome 21 could be responsible for the main features of Down syndrome. To define and… Expand