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ETS2 wt Allele

Known as: ETS2, v-ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2, v-ETS Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian) wt Allele 
The human ETS2 wild-type allele is located in the vicinity of 21q22 and is approximately 19 kb in length. This allele, which encodes protein C-ets-2… Expand
National Institutes of Health

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9 relations
21q22.2ETS2 ProteinHomo sapiensMacrophage Differentiation Pathway
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Broader (1)

ETS2 gene

Papers overview

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2012
2012
Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells
E26 transformation-specific sequence (ETS)-2 is a transcriptional modulator located on chromosome 21, alterations in its… Expand
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Highly Cited
2010
Highly Cited
2010
An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis.
Tumor-associated macrophages (TAM) are implicated in breast cancer metastasis, but relatively little is known about the… Expand
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2006
2006
Ets2 transcription factor in normal and neoplastic human breast tissue.
The Ets family of transcription factors regulate the expression of multiple genes involved in tumour formation and progression… Expand
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2004
2004
Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells.
Ets2 is a member of the Ets family of transcription factors that in humans comprise 25 distinct members. Various Ets-domain… Expand
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2003
2003
Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis
Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this… Expand
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2000
2000
Role of Ets2 in cyclic AMP regulation of the human chorionic gonadotropin β promoter
Activation of the human chorionic gonadotropin beta (hCGbeta) by the protein kinase A (PKA) pathway has been shown to occur… Expand
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Highly Cited
1999
Highly Cited
1999
The Ets2 transcription factor inhibits apoptosis induced by colony-stimulating factor 1 deprivation of macrophages through a Bcl-xL-dependent mechanism.
Bcl-xL, a member of the Bcl-2 family, inhibits apoptosis, and its expression is regulated at the transcriptional level, yet… Expand
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1999
1999
Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1.
Interleukin-5 (IL-5), expressed primarily by type-2 T helper (Th2) cells, plays an important role in the development of allergic… Expand
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Highly Cited
1998
Highly Cited
1998
Defective trophoblast function in mice with a targeted mutation of Ets2.
Members of the Ets family of transcription factors mediate transcriptional responses of multiple signaling pathways in diverse… Expand
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1994
1994
Myb and Ets related transcription factors are required for activity of the human lck type I promoter.
The lck gene, which encodes a lymphoid-specific Src family tyrosine kinase, is transcribed from two promoters that are… Expand
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