2-phenylindole

 
National Institutes of Health

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2012
2012
Synthesis, molecular docking study and antitumor activity of novel 2-phenylindole derivatives.
The starting material, 4-(1-indol-2-yl)phenol 1 was obtained via Fischer synthesis. Vilsmeir Haack(')s formylation of 1 gave the… (More)
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2009
2009
CoMFA and docking studies of 2-phenylindole derivatives with anticancer activity.
Three-dimensional (3D) quantitative structure-activity relationship (QSAR) and docking studies of 43 tubulin inhibitors, 2… (More)
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2008
2008
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents.
Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of… (More)
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2007
2007
Preliminary evaluation of rat kidney aldose reductase inhibitory activity of 2-phenylindole derivatives: affiliation to antioxidant activity
Diabetic complications including nephropathy, neuropathy, and cataract are leading causes of end-stage renal diseases and… (More)
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2006
2006
Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.
The bacterial hyaluronan lyases (Hyals) that degrade hyaluronan, an important component of the extracellular matrix, are involved… (More)
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2006
2006
Investigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives: discussion on possible antioxidant mechanisms and comparison with melatonin.
Oxidative stress has been implicated in the development of many neurodegenerative diseases and also responsible from aging and… (More)
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1998
1998
Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization.
The aim of this study was the identification of the essential structural elements in the 12-formyl-5,6-dihydroindolo[2, 1-a… (More)
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1996
1996
2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumor activity
The 2-phenylindole system has been identified as a suitable structure for the design of non-steroidal pure estrogen antagonists… (More)
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1994
1994
1-carbamoylalkyl-2-phenylindoles: Relationship between side chain structure and estrrogen antagonism
The 2-phenylindole system has proved to be a versatile structure for the design of potent antiestrogens, especially when… (More)
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1984
1984
2-Phenylindoles. Relationship between structure, estrogen receptor affinity, and mammary tumor inhibiting activity in the rat.
A number of 2-phenylindole derivatives with one hydroxy group in the meta or para position of the phenyl ring and a second one in… (More)
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