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2-hydroxyestradiol

Known as: 2-Hydroxy-17beta-Estradiol, 2-OH-Estradiol, 2-Hydroxyestradiol-17beta 
A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 2 by the CYP450 enzymes 1A1/1A2… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

2-hydroxyestradiol, (17alpha)-isomer2-hydroxyestradiol-17 beta

Broader (1)

Estradiol
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells
Highly Cited
2002
Highly Cited
2002
Association of CYP1B1 polymorphisms and breast cancer risk.
Cytochrome P450 1B1 catalyzes the conversion of 17-beta-estradiol (E2) to thecatechol estrogen metabolites 2-OH-E2 and 4-OH-E2… 
Highly Cited
2001
Highly Cited
2001
Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.
We characterized the NADPH-dependent metabolism of 17beta-estradiol (E2) by liver microsomes from 21 male and 12 female human… 
1998
1998
Metabolic activation and formation of DNA adducts of hexestrol, a synthetic nonsteroidal carcinogenic estrogen.
Hexestrol (HES), a synthetic nonsteroidal estrogen, is carcinogenic in Syrian golden hamsters. The major metabolite of HES is its… 
Highly Cited
1994
Highly Cited
1994
Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol, ascorbigen, or β-naphthaflavone: A comparison of stable isotope dilution gas chromatography-mass spectrometry…
Highly Cited
1992
Highly Cited
1992
Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens.
Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these… 
Highly Cited
1990
Highly Cited
1990
The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogen-induced carcinogenesis.
O-Methylation of catecholestrogens catalyzed by catechol-O-methyltransferase provides a major route for the rapid metabolic… 
Highly Cited
1983
Highly Cited
1983
Kinetics of catechol estrogen-estrogen receptor dissociation: A possible factor underlying differences in catechol estrogen biological activity
Highly Cited
1976
Highly Cited
1976
Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates.
Highly Cited
1976
Highly Cited
1976
Convenient large scale preparation of catechol estrogens
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