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2-hydroxyestradiol

Known as: 2-Hydroxy-17beta-Estradiol, 2-OH-Estradiol, 2-Hydroxyestradiol-17beta 
A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 2 by the CYP450 enzymes 1A1/1A2… Expand
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Exposure to estrogens is associated with increased risk of breast and other types of human cancer. Estrogens are converted to… Expand
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Highly Cited
2003
Highly Cited
2003
We systematically characterized the oxidative metabolites of 17beta-estradiol and estrone formed by 15 human cytochrome P450 (CYP… Expand
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Highly Cited
2001
Highly Cited
2001
The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and… Expand
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Highly Cited
2000
Highly Cited
2000
Activation of 17beta-estradiol (E2) through the formation of catechol estrogen metabolites, 2-OH-E2 and 4-OH-E2, and the C… Expand
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Highly Cited
1999
Highly Cited
1999
Estrogens have been suggested for the treatment of neurodegenerative disorders, including stroke, because of their… Expand
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Highly Cited
1999
Highly Cited
1999
Considering the physiologic importance of the steroid response, which is regulated in part by steroid levels in a given tissue… Expand
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Highly Cited
1997
Highly Cited
1997
The rat estrogen receptor (ER) exists as two subtypes, ERα and ERβ, which differ in the C-terminal ligand binding domain and in… Expand
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Highly Cited
1997
Highly Cited
1997
The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain… Expand
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Highly Cited
1994
Highly Cited
1994
In the present study, the antioxidant effects of estradiol (E2) and 2-hydroxyestradiol (2-OHE2) on microsomal lipid peroxidation… Expand
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Highly Cited
1994
Highly Cited
1994
It has previously been proposed that redox cycling between catechol estrogens and their quinones, mediated by cytochrome P450… Expand
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