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2-hydroxyestradiol

Known as: 2-Hydroxy-17beta-Estradiol, 2-OH-Estradiol, 2-Hydroxyestradiol-17beta 
A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 2 by the CYP450 enzymes 1A1/1A2… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

2-hydroxyestradiol, (17alpha)-isomer2-hydroxyestradiol-17 beta

Broader (1)

Estradiol
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells
Highly Cited
2002
Highly Cited
2002
Association of CYP1B1 polymorphisms and breast cancer risk.
Cytochrome P450 1B1 catalyzes the conversion of 17-beta-estradiol (E2) to thecatechol estrogen metabolites 2-OH-E2 and 4-OH-E2… 
2002
2002
2-Hydroxyestradiol attenuates renal disease in chronic puromycin aminonucleoside nephropathy.
It has been previously shown that 2-hydroxyestradiol (2-OHE) attenuates the development of renal disease in genetic nephropathy… 
Highly Cited
2001
Highly Cited
2001
Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.
We characterized the NADPH-dependent metabolism of 17beta-estradiol (E2) by liver microsomes from 21 male and 12 female human… 
Highly Cited
1994
Highly Cited
1994
Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol, ascorbigen, or β-naphthaflavone: A comparison of stable isotope dilution gas chromatography-mass spectrometry…
Highly Cited
1992
Highly Cited
1992
Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens.
Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these… 
Highly Cited
1990
Highly Cited
1990
The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogen-induced carcinogenesis.
O-Methylation of catecholestrogens catalyzed by catechol-O-methyltransferase provides a major route for the rapid metabolic… 
Highly Cited
1983
Highly Cited
1983
Kinetics of catechol estrogen-estrogen receptor dissociation: A possible factor underlying differences in catechol estrogen biological activity
Highly Cited
1976
Highly Cited
1976
Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates.
Highly Cited
1976
Highly Cited
1976
Convenient large scale preparation of catechol estrogens
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