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2-hydroxyestradiol

Known as: 2-Hydroxy-17beta-Estradiol, 2-OH-Estradiol, 2-Hydroxyestradiol-17beta 
A metabolite formed during the metabolism of 17beta-estradiol by hydroxylation of the carbon at position 2 by the CYP450 enzymes 1A1/1A2… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

2-hydroxyestradiol, (17alpha)-isomer2-hydroxyestradiol-17 beta

Broader (1)

Estradiol
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Antioxidant activities of estrogens against aqueous and lipophilic radicals; differences between phenol and catechol estrogens.
Highly Cited
1999
Highly Cited
1999
Neuroprotection by Estrogens in a Mouse Model of Focal Cerebral Ischemia and in Cultured Neurons: Evidence for a Receptor-Independent Antioxidative Mechanism
Estrogens have been suggested for the treatment of neurodegenerative disorders, including stroke, because of their… 
Highly Cited
1999
Highly Cited
1999
The Monkey and Human Uridine Diphosphate-Glucuronosyltransferase UGT1A9, Expressed in Steroid Target Tissues, Are Estrogen-Conjugating Enzymes.
Considering the physiologic importance of the steroid response, which is regulated in part by steroid levels in a given tissue… 
Highly Cited
1994
Highly Cited
1994
DNA damage caused by reactive oxygen species originating from a copper-dependent oxidation of the 2-hydroxy catechol of estradiol.
It has previously been proposed that redox cycling between catechol estrogens and their quinones, mediated by cytochrome P450… 
Highly Cited
1994
Highly Cited
1994
Steroid sulfation by expressed human cytosolic sulfotransferases
Review
1990
Review
1990
Genotoxic effects of estrogens.
  • J. Liehr
  • Mutation research
  • 1990
  • Corpus ID: 25712773
Highly Cited
1990
Highly Cited
1990
Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.
Highly Cited
1986
Highly Cited
1986
Urinary estrogen profile determination in young Finnish vegetarian and omnivorous women.
Highly Cited
1986
Highly Cited
1986
Cytochrome P-450-mediated redox cycling of estrogens.
Highly Cited
1977
Highly Cited
1977
Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites.
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